Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zbigniew Mrowiec"'
Autor:
Manoochehr Khorshidi, Zbigniew Mrowiec, Leslie Oleksowicz, Janice P. Dutcher, E G Puszkin, Edward L. Schwartz
Publikováno v:
Thrombosis Research. 79:261-274
Tumor cell induced platelet aggregation is thought to be an early step in the metastatic process. Here we show that platelet aggregation induced by MCF-7 cells is mediated, in part, through an ADP-dependent mechanism based on inhibition of aggregatio
Publikováno v:
Thrombosis and Haemostasis. 72:302-308
SummaryThe effect of IL-6 on in vitro platelet function was investigated. Platelet-rich plasma (PRP) incubated with IL-6 showed a dose dependent enhancement of agonist induced maximum aggregation (AIMA) and secretion of thromboxane B2 (TXB2) as measu
Apyrase, ascorbic acid and aprotinin ameliorate the storage lesion in pelleted platelet preparations
Autor:
P. Lalezari, De Leon-Fernandez M, Leslie Oleksowicz, Janice P. Dutcher, E G Puszkin, Zbigniew Mrowiec
Publikováno v:
Biotechnichistochemistry : official publication of the Biological Stain Commission. 72(5)
To evaluate the effect of apyrase, ascorbic acid and aprotinin (AAA) in preventing platelet activation during storage, 12 sets of platelet concentrates (PCs), were treated with AAA and evaluated at days 1, 3, and 5 utilizing platelet functional and m
Autor:
M Khorshidi, D Zuckerman, M. De Leon-Fernandez, E G Puszkin, Leslie Oleksowicz, Zbigniew Mrowiec, Janice P. Dutcher
Publikováno v:
Transfusion. 36(1)
Background: Platelet activation is an important factor impeding the clinical effectiveness of platelet transfusions. In this study, platelet concentrates (PCs) were prepared by a novel suspended-bag buffy coat technique that was followed by the addit
Publikováno v:
Cancer investigation. 14(4)
Platelet function in 12 cancer patients was studied sequentially over 97 hr of interleukin-6 (IL-6) daily bolus or continuous infusion (C.I.) therapy. During this period, enhanced ex vivo agonist-induced platelet maximum aggregation (MA) was parallel
Publikováno v:
American journal of hematology. 48(2)
The in vitro effect of IL-6 on platelet activation was investigated. When human platelets were incubated with high (1,000 ng/ml) or low (1 ng/ml) dose IL-6, expression of GMP-140 was enhanced by 42% (N = 6; P < 0.009) and 46% (N = 6; P < 0.061) in 1
Publikováno v:
American journal of hematology. 45(3)
Platelet function in 16 patients with metastatic renal cell carcinoma and melanoma was studied sequentially over the first 96 hr of treatment with moderate and high-dose interleukin-2 (IL-2). During the first 96 hr of therapy, an increased ex vivo pl