Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Zbigniew J. Witczak"'
Autor:
Grzegorz Mlostoń, Katarzyna Urbaniak, Marcin Palusiak, Zbigniew J. Witczak, Ernst-Ulrich Würthwein
Publikováno v:
Molecules, Vol 28, Iss 21, p 7348 (2023)
The in situ-generated N-aryl nitrile imines derived from trifluoroacetonitrile smoothly undergo (3+2)-cycloadditions onto the enone fragment of the levoglucosenone molecule, yielding the corresponding, five-membered cycloadducts. In contrast to the
Externí odkaz:
https://doaj.org/article/55184a46cdd44b87b3ace66b26a348c9
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Micro/nanocapsules would have many more applications if we were able to controllably populate their surface with various chemical moieties. The present review introduces a novel variant of interfacial polymerization (IP) as a very robust method of ma
Externí odkaz:
https://doaj.org/article/5009af9082c44c088105877475d69f6d
Publikováno v:
Arkivoc. 2021:268-279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8fa335a9228d437409875d19b4b62c8
https://doi.org/10.24820/ark.5550190.p011.394
https://doi.org/10.24820/ark.5550190.p011.394
Publikováno v:
Current Medicinal Chemistry. 26:1483-1493
DNA double-strand breaks are considered one of the most lethal forms of DNA damage. Many effective anticancer therapeutic approaches used chemical and physical methods to generate DNA double-strand breaks in the cancer cells. They include: IR and dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5f0dfec2175a4fe827810f21b4d65c
https://doi.org/10.2174/0929867325666180214113154
https://doi.org/10.2174/0929867325666180214113154
Autor:
Holly Arcure, Rachael E. Hohol, Zbigniew J. Witczak, Peter R. Andreana, Kristin Kirschbaum, Donald E. Mencer, Roman Bielski
Publikováno v:
Tetrahedron. 74:7303-7309
A library of exo-cyclic carbohydrate enones 2–13 were prepared via a base-catalyzed, highly stereoselective aldol condensation of dihydrolevoglucosenone 1 (cyrene) with various aromatic aldehydes. In the case of 4-chlorobenzaldehyde as a reactant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba4983fdd8a1a308fc55fcd315f96f9
https://doi.org/10.1016/j.tet.2018.10.049
https://doi.org/10.1016/j.tet.2018.10.049
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry, Vol 8 (2020)
Micro/nanocapsules would have many more applications if we were able to controllably populate their surface with various chemical moieties. The present review introduces a novel variant of interfacial polymerization (IP) as a very robust method of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f03a2dd0ee8bf4ffb6c2763bfca2bd5
Autor:
Malwina Kawka, Anna Brzostek, Małgorzata Korycka-Machała, Jakub Pawełczyk, Jarosław Dziadek, Bozena Dziadek, Dominik Strapagiel, Adrian Bekier, Sebastian Rykowski, Paulina Borówka, Agnieszka B. Olejniczak, Zbigniew J. Witczak
Publikováno v:
Cells
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 603 (2020)
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 603 (2020)
We have recently found that selected thio-disaccharides possess bactericidal effects against Mycobacterium tuberculosis but not against Escherichia coli or Staphylococcus aureus. Here, we selected spontaneous mutants displaying resistance against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87ba5bbe14d047da9d15cc5922caa8f
http://europepmc.org/articles/PMC7140425
http://europepmc.org/articles/PMC7140425
This brief review discusses some new developments in the functionalized carb pharmacophore (FCP) concept introduced by us in 2014. While the examples concentrate mainly on biological data of selected newly designed carbohydrate molecules, the chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c401a13205d9fd3a2950e64bd96903
https://doi.org/10.1039/9781788013864-00130
https://doi.org/10.1039/9781788013864-00130
Publikováno v:
Tetrahedron Letters. 58:4069-4072
Stereoselective synthesis of exocyclic enones 10–17 via a base-catalyzed direct aldol condensation between dihydrolevoglucosenone 1 and heterocyclic aldehydes 2–9 is described. The reaction is performed under mild conditions and is applicable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60b612321a74bf77f31210c6e4994870
https://doi.org/10.1016/j.tetlet.2017.09.028
https://doi.org/10.1016/j.tetlet.2017.09.028
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1210-1214
Thio-sugars have been described as potent inhibitors of cancer cell growth but the detailed mechanism of action remains unknown. Herein we investigated the mechanism of their anticancer action in the HeLa cell line. We investigated two thio-sugars: 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a4a97c775e133418d5a4d36953a3a0
https://doi.org/10.1016/j.bmcl.2017.01.011
https://doi.org/10.1016/j.bmcl.2017.01.011