Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Zaza M Ndhlovu"'
Autor:
Thandeka Nkosi, Caroline Chasara, Andrea O Papadopoulos, Tiza L Nguni, Farina Karim, Mahomed-Yunus S Moosa, Inbal Gazy, Kondwani Jambo, COMMIT-KZN-Team, Willem Hanekom, Alex Sigal, Zaza M Ndhlovu
Publikováno v:
eLife, Vol 11 (2022)
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease, but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the impact of HIV infection on the quality and epitope specificity of SARS-
Externí odkaz:
https://doaj.org/article/0fc2cdcb43f140b3817a81de56980d99
Autor:
Funsho Ogunshola, Gursev Anmole, Rachel L. Miller, Emily Goering, Thandeka Nkosi, Daniel Muema, Jaclyn Mann, Nasreen Ismail, Denis Chopera, Thumbi Ndung’u, Mark A. Brockman, Zaza M Ndhlovu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely
Externí odkaz:
https://doaj.org/article/8b5dac89542c4c2da2cce8fc2d1bce1e
Autor:
Trevor Khaba, Andrea Olga Papadopoulos, Thandeka Nkosi, Sifundo Nxele, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStudying diseased human tissues offers better insights into the intricate interactions between pathogens and the human host. In conditions such as HIV and cancers, where diseases primarily manifest in tissues, peripheral blood studies are
Externí odkaz:
https://doaj.org/article/01aa2430acaa406abdf464ada98acc7e
Autor:
Tiza L. Ng’uni, Vernon Musale, Thandeka Nkosi, Jonathan Mandolo, Memory Mvula, Clive Michelo, Farina Karim, Mohomed Yunus S. Moosa, Khadija Khan, Kondwani Charles Jambo, Willem Hanekom, Alex Sigal, William Kilembe, Zaza M. Ndhlovu
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundUnderstanding how HIV affects SARS-CoV-2 immunity is crucial for managing COVID-19 in sub-Saharan populations due to frequent coinfections. Our previous research showed that unsuppressed HIV is associated with weaker immune responses to SAR
Externí odkaz:
https://doaj.org/article/bf768e1f550c47c380042cc762cd9c8b
Autor:
Bongiwe Mahlobo, Faatima Laher, Werner Smidt, Funsho Ogunshola, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu
Publikováno v:
BMC Immunology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a novel subset of regulato
Externí odkaz:
https://doaj.org/article/44ea8b47cf83442abec00ae4b385cecd
Autor:
Leonard Mvaya, Trevor Khaba, Agness E. Lakudzala, Thandeka Nkosi, Ndaru Jambo, Innocent Kadwala, Anstead Kankwatira, Priyanka D. Patel, Melita A. Gordon, Tonney S. Nyirenda, Kondwani C. Jambo, Zaza M. Ndhlovu
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
The duodenum is a major site of HIV persistence during suppressive antiretroviral therapy despite harboring abundant tissue-resident memory (Trm) CD8+ T cells. The role of duodenal Trm CD8+ T cells in viral control is still not well defined. We exami
Externí odkaz:
https://doaj.org/article/84295747973a43d78025a32a2b211968
Autor:
Funsho J. Ogunshola, Werner Smidt, Anneta F. Naidoo, Thandeka Nkosi, Thandekile Ngubane, Trevor Khaba, Omolara O. Baiyegunhi, Bongiwe Mahlobo, Sam Rasehlo, Namani Ngema, Ismail Jajbhay, Krista L. Dong, Veron Ramsuran, Johan Pansegrouw, Thumbi Ndung’u, Bruce D. Walker, Tulio de Oliveria, Zaza M. Ndhlovu
Publikováno v:
Blood Advances. 6:1904-1916
CD8+ T cells play an important role in HIV control. However, in human lymph nodes (LNs), only a small subset of CD8+ T cells express CXCR5, the chemokine receptor required for cell migration into B-cell follicles, which are major sanctuaries for HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0798d0ff69522fca50d5bdc3a74e238
https://doi.org/10.1182/bloodadvances.2021006001
https://doi.org/10.1182/bloodadvances.2021006001
Autor:
Monique Nijhuis, Steven G. Deeks, Richard Dunham, Marein A. W. P. de Jong, Marein de Jong, Thanyawee Puthanakit, Mirko Paiardini, Santiago Perez Patrigeon, Krista L. Dong, Jan van Lunzen, Luke Jasenosky, Jessica Salzwedel, Simon Collins, Katharine J. Bar, Frank Mardarelli, Jeffrey T. Safrit, Jeremy Sugarman, Alex Schneider, Nancie M. Archin, Zaza M. Ndhlovu, Joel N. Blankson, Zabrina L. Brumme, Hans-Peter Kiem, Gaerolwe Masheto, Beatriz Mothe, Karine Dubé, Katherine Luzuriaga, Jennifer Power, Sarah Fidler, Richard Jefferys, Fu Sheng Wang, Jeff Taylor, Kumitaa Theva Das, Boro Dropulic, Kai Deng, Devi SenGupta, Sharon Lewin, Marina Caskey, Susana T. Valente, Siegfried Schwarze, Nicolas Chomont, R. Brad Jones, Ole S. Søgaard, Paula M. Cannon, Olivier Lambotte, Edward Nelson Kankaka, Gabriela Turk, Christina Antoniadi, Udom Likhitwonnawut, Caroline T. Tiemessen, Pablo Tebas, Rosanne Lamplough, Cissy Kityo, Fernanda Heloise Côrtes, Melannie Ott, Rose Nabatanzi, Oguzhan Latif Nuh, Mitch Matoga, Linos Vandekerckhove, J. Victor Garcia, Thumbi Ndung'u, Bonnie J. Howell, Aurelio Orta-Resendiz, Ricardo Sobhie Diaz, Michael Louella, Ann Chahroudi, Deborah Persaud, Stephan Dressler, Josephine Nabukenya, Sharon R Lewin
Publikováno v:
Nature Medicine. 27:2085-2098
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45d4a1ed300ed64c27c2b6dc382ca1a
https://doi.org/10.1038/s41591-021-01590-5
https://doi.org/10.1038/s41591-021-01590-5
Autor:
Tawanda Mandizvo, Nombali Gumede, Bongiwe Ndlovu, Siphiwe Ndlovu, Jaclyn K. Mann, Denis R. Chopera, Lanish Singh, Krista L. Dong, Bruce D. Walker, Zaza M. Ndhlovu, Christy L. Lavine, Michael S. Seaman, Kamini Gounder, Thumbi Ndung’u
Publikováno v:
Journal of virology. 96(24)
Broadly neutralizing antibodies (bNAbs) for HIV-1 prevention or cure strategies must inhibit transmitted/founder and reservoir viruses. Establishing sensitivity of circulating viruses to bNAbs and genetic patterns affecting neutralization variability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfae81221806138d825fbf66a9e4e78
https://pubmed.ncbi.nlm.nih.gov/36453881
https://pubmed.ncbi.nlm.nih.gov/36453881
Autor:
Samuel W. Kazer, Alex K. Shalek, Mary Dong, J. Christopher Love, Sarah K. Nyquist, Shaina L. Carroll, Alasdair Leslie, Amber Moodley, Jose Ordovas-Montanes, Toby Aicher, Emily B. Wong, Krista L. Dong, Zaza M. Ndhlovu, Carly G. K. Ziegler, Vincent N. Miao, Nasreen Ismail, Thumbi Ndung'u, Daniel M. Muema, Ang A. Tu, Bruce D. Walker, Bonnie Berger
Publikováno v:
Nature Medicine
Nat Med
Nat Med
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell–cell cooperativity in evolving human immune responses remain poorly understood. Single-cell RNA-sequencing (scRNA-seq) represents a pow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b6d6ff066fb06a363149e07e3c0e6c
https://doi.org/10.1038/s41591-020-0799-2
https://doi.org/10.1038/s41591-020-0799-2