Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Zaza M"'
Autor:
Trevor Khaba, Andrea Olga Papadopoulos, Thandeka Nkosi, Sifundo Nxele, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStudying diseased human tissues offers better insights into the intricate interactions between pathogens and the human host. In conditions such as HIV and cancers, where diseases primarily manifest in tissues, peripheral blood studies are
Externí odkaz:
https://doaj.org/article/01aa2430acaa406abdf464ada98acc7e
Autor:
Tiza L. Ng’uni, Vernon Musale, Thandeka Nkosi, Jonathan Mandolo, Memory Mvula, Clive Michelo, Farina Karim, Mohomed Yunus S. Moosa, Khadija Khan, Kondwani Charles Jambo, Willem Hanekom, Alex Sigal, William Kilembe, Zaza M. Ndhlovu
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundUnderstanding how HIV affects SARS-CoV-2 immunity is crucial for managing COVID-19 in sub-Saharan populations due to frequent coinfections. Our previous research showed that unsuppressed HIV is associated with weaker immune responses to SAR
Externí odkaz:
https://doaj.org/article/bf768e1f550c47c380042cc762cd9c8b
Autor:
Bongiwe Mahlobo, Faatima Laher, Werner Smidt, Funsho Ogunshola, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu
Publikováno v:
BMC Immunology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a novel subset of regulato
Externí odkaz:
https://doaj.org/article/44ea8b47cf83442abec00ae4b385cecd
Autor:
Omolara O. Baiyegunhi, Jaclyn Mann, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Funsho Ogunshola, Caroline Chasara, Nasreen Ismail, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Krista L. Dong, Bruce D. Walker, Thumbi Ndung’u, Zaza M. Ndhlovu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Despite antiretroviral therapy, HIV often persists in tissue sanctuary sites. In this work, authors investigate HIV persistence and T cell responses in lymph node biopsies obtained from individuals who initiated antiretroviral therapy in Fiebig stage
Externí odkaz:
https://doaj.org/article/50e73a5e9c94475094bccd50e686c5cb
Autor:
Thandeka Nkosi, Caroline Chasara, Andrea O Papadopoulos, Tiza L Nguni, Farina Karim, Mahomed-Yunus S Moosa, Inbal Gazy, Kondwani Jambo, COMMIT-KZN-Team, Willem Hanekom, Alex Sigal, Zaza M Ndhlovu
Publikováno v:
eLife, Vol 11 (2022)
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease, but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the impact of HIV infection on the quality and epitope specificity of SARS-
Externí odkaz:
https://doaj.org/article/0fc2cdcb43f140b3817a81de56980d99
Autor:
Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann, Thumbi Ndung’u
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Introduction Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed th
Externí odkaz:
https://doaj.org/article/12144ae325134e809d1d43e98283a822
Autor:
Leonard Mvaya, Trevor Khaba, Agness E. Lakudzala, Thandeka Nkosi, Ndaru Jambo, Innocent Kadwala, Anstead Kankwatira, Priyanka D. Patel, Melita A. Gordon, Tonney S. Nyirenda, Kondwani C. Jambo, Zaza M. Ndhlovu
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
The duodenum is a major site of HIV persistence during suppressive antiretroviral therapy despite harboring abundant tissue-resident memory (Trm) CD8+ T cells. The role of duodenal Trm CD8+ T cells in viral control is still not well defined. We exami
Externí odkaz:
https://doaj.org/article/84295747973a43d78025a32a2b211968
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Following the discovery of HIV as a causative agent of AIDS, the expectation was to rapidly develop a vaccine; but thirty years later, we still do not have a licensed vaccine. Progress has been hindered by the extensive genetic variability of HIV and
Externí odkaz:
https://doaj.org/article/52b63c675650477b943e3402a0b6e530
Autor:
Funsho Ogunshola, Gursev Anmole, Rachel L. Miller, Emily Goering, Thandeka Nkosi, Daniel Muema, Jaclyn Mann, Nasreen Ismail, Denis Chopera, Thumbi Ndung’u, Mark A. Brockman, Zaza M Ndhlovu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely
Externí odkaz:
https://doaj.org/article/8b5dac89542c4c2da2cce8fc2d1bce1e
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