Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

Autor: Dogukan Mizrak, Hanna Mendes Levitin, Ana C. Delgado, Valerie Crotet, Jinzhou Yuan, Zayna Chaker, Violeta Silva-Vargas, Peter A. Sims, Fiona Doetsch

Publikováno v: Cell Reports, Vol 26, Iss 2, Pp 394-406.e5 (2019)

Summary: The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural stem cells exhibit features of astrocytes, have a regional identity, and depending on their location in the lateral or septal wall of the lateral ventr

Externí odkaz: https://doaj.org/article/31e0175e5e654690b98c8d5d341d81d0

Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis.

Autor: Ralph Epaud, Flore Aubey, Jie Xu, Zayna Chaker, Maud Clemessy, Alexandre Dautin, Karmène Ahamed, Monique Bonora, Nadia Hoyeau, Jean-François Fléjou, Arnaud Mailleux, Annick Clement, Alexandra Henrion-Caude, Martin Holzenberger

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48071 (2012)

BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R). Lethal

Externí odkaz: https://doaj.org/article/79582e64dd85445aa1c5f11cf009ffd6

Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis

Autor: Zayna Chaker, Fiona Doetsch, Alex Paul

Publikováno v: Science. 356:1383-1386

Neural stem cells (NSCs) in specialized niches in the adult mammalian brain generate neurons throughout life. NSCs in the adult mouse ventricular-subventricular zone (V-SVZ) exhibit a regional identity and, depending on their location, generate disti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021e68b968ae366c2104a228b9ba82c0
https://doi.org/10.1126/science.aal3839

CaMKIIα Expression Defines Two Functionally Distinct Populations of Granule Cells Involved in Different Types of Odor Behavior

Autor: Delphine Hardy, Isabelle Caillé, Laura Daroles, Paul De Koninck, Sarah Malvaut, Martin Holzenberger, Daniel Côté, Simona Gribaudo, Marie-Anne Lebel-Cormier, Linda Suzanne David, Zayna Chaker, Armen Saghatelyan, Alain Trembleau, Simon Labrecque

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2017, ⟨10.1016/j.cub.2017.09.058⟩
Current Biology-CB, 2017, 27 (21), pp.3315-3329.e6. ⟨10.1016/j.cub.2017.09.058⟩
Current Biology-CB, 2017, ⟨10.1016/j.cub.2017.09.058⟩

Granule cells (GCs) in the olfactory bulb (OB) play an important role in odor information processing. Although they have been classified into various neurochemical subtypes, the functional roles of these subtypes remain unknown. We used in vivo two-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53dd2220c8911292036f488cb0a8fad
https://hal.sorbonne-universite.fr/hal-01628285

Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway

Autor: Philippe Lacube, Isabelle Caillé, Jean-Baptiste Caron, Caroline George, Zayna Chaker, Marija Petrovska, Martin Holzenberger

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2016, 41, pp. 64-72. ⟨10.1016/j.neurobiolaging.2016.02.008⟩
Neurobiology of Aging, 2016, 41, pp. 64-72. ⟨10.1016/j.neurobiolaging.2016.02.008⟩
Neurobiology of Aging, Elsevier, 2016, 41, pp. 64-72. 〈10.1016/j.neurobiolaging.2016.02.008〉

International audience; Hypothalamic tanycytes are specialized glial cells lining the third ventricle. They are recently identified as adult stem and/or progenitor cells, able to self-renew and give rise to new neurons postnatally. However, the long-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b648fa1bd26c6b0350ae7a11f0bec2c
https://hal.sorbonne-universite.fr/hal-01297761/document