Role of macrophages during skeletal muscle regeneration and hypertrophy—Implications for immunomodulatory strategies

Autor: Clara Bernard, Aliki Zavoriti, Quentin Pucelle, Bénédicte Chazaud, Julien Gondin

Publikováno v: Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)

Abstract Skeletal muscle is a plastic tissue that regenerates ad integrum after injury and adapts to raise mechanical loading/contractile activity by increasing its mass and/or myofiber size, a phenomenon commonly refers to as skeletal muscle hypertr

Externí odkaz: https://doaj.org/article/b7fe5aeb78f9427ebce5de3e5513a715

The mouse HP1 proteins are essential for preventing liver tumorigenesis

Autor: Marine Pratlong, Eric Fabbrizio, Lakdhar Khellaf, Nelly Pirot, Amélie Sarrazin, Damien Grégoire, Yannick Perez, Shefqet Hajdari, Jean-Yohan Noël, Eric Julien, Nehmé Saksouk, Aliki Zavoriti, Florence Cammas, Céline Graber, Célia Barrachina

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (13), pp.2676-2691. ⟨10.1038/s41388-020-1177-8⟩

International audience; Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin associated proteins HP1 are dispensable for hepatocytes survival but are essential within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261f982476fcd05a475d58373edb93fb
https://doi.org/10.1038/s41388-020-1177-8

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Autor: Lara Gales, Camille Montersino, Marc Conti, Pierre Bories, Courtney D. DiNardo, Brandon Nicolay, Fabien Jourdan, Nicolas Broin, Mohsen Hosseini, Guillaume Cognet, Yves Gibon, Marie Sabatier, Tony Kaoma, Marina Konopleva, Lucille Stuani, Mathilde Gotanègre, Christian Recher, Laurent Fernando, Vera Pancaldi, Nathalie Poupin, Estelle Saland, Jean-Emmanuel Sarry, Joseph R. Marszalek, Andrei Turtoi, Thomas Farge, Feng Wang, Yves Collette, Laurent Le Cam, Madi Y. Cissé, Cédric Cassan, Alexis Hucteau, Claudie Bosc, Natalia Baran, Sebastien Ronseaux, Aliki Zavoriti, François Fenaille, Florence Castelli, Laetitia K. Linares, Evgenia Turtoi, Emeline Chu-Van, Martin Carroll, Pierre-Luc Mouchel, Mary A. Selak, Guillaume Cazals, Emeline Boet, Rémy Castellano, Floriant Bellvert, Norbert Vey, Clément Larrue, Koichi Takahashi, Ambrine Sahal, Sylvain Loric, Jean-Charles Portais

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (5), ⟨10.1084/jem.20200924⟩
The Journal of Experimental Medicine

Stuani et al. demonstrate that IDH mutant AML cells display an enhanced mitochondrial phenotype, which is not reversed by IDH mutant inhibitors. This study provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb2b30f8b948c067d643d1119fbb0e
https://amu.hal.science/hal-03563454/file/jStuani_em_20200924.pdf

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The mouse HP1 proteins are essential for preventing liver tumorigenesis

Autor: Nehmé, Saksouk, Shefqet, Hajdari, Yannick, Perez, Marine, Pratlong, Célia, Barrachina, Céline, Graber, Damien, Grégoire, Aliki, Zavoriti, Amélie, Sarrazin, Nelly, Pirot, Jean-Yohan, Noël, Lakhdar, Khellaf, Eric, Fabbrizio, Eric, Julien, Florence M, Cammas

Publikováno v: Oncogene. 39(13)

Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin-associated proteins HP1 are dispensable for hepatocytes survival but are essential within hepatocytes to prevent l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d590e9afe6a5505ad43994bd91171c4
https://pubmed.ncbi.nlm.nih.gov/32020053