Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Zaverio M Ruggeri"'
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55094 (2013)
We have engineered a transgenic mouse on a C57BL/6 background that bears a floxed Itga2 gene. The crossing of this mouse strain to transgenic mice expressing Cre recombinase driven by the megakaryocyte (MK)-specific Pf4 promoter permits the condition
Externí odkaz:
https://doaj.org/article/c9f4b98311de41c1aafd3b468cb9b9ed
Autor:
Sachiko Kanaji, Yosuke Morodomi, Hartmut Weiler, Alessandro Zarpellon, Robert R. Montgomery, Zaverio M. Ruggeri, Taisuke Kanaji
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Type 2B von Willebrand disease (VWD) is caused by gain-of-function mutations in von Willebrand factor (VWF). Increased VWF affinity for GPIba results in loss of high molecular weight multimers and enhanced platelet clearance, both contributing to the
Externí odkaz:
https://doaj.org/article/5292c9accfd547d095570b33387baee9
Autor:
Sarah Beck, Patricia Öftering, Renhao Li, Katherina Hemmen, Magdolna Nagy, Yingchun Wang, Alessandro Zarpellon, Michael K. Schuhmann, Guido Stoll, Zaverio M. Ruggeri, Katrin G. Heinze, Johan W. M. Heemskerk, Wolfram Ruf, David Stegner, Bernhard Nieswandt
Publikováno v:
Nat Cardiovasc Res
The activation of platelets and coagulation at vascular injury sites is crucial for hemostasis but can promote thrombosis and inflammation in vascular pathologies. Here, we delineate an unexpected spatio-temporal control mechanism of thrombin activit
Autor:
Yosuke Morodomi, Sachiko Kanaji, Brian M. Sullivan, Alessandro Zarpellon, Jennifer N. Orje, Eric Won, Ryan Shapiro, Xiang-Lei Yang, Wolfram Ruf, Paul Schimmel, Zaverio M. Ruggeri, Taisuke Kanaji
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(48)
Platelets play a role not only in hemostasis and thrombosis, but also in inflammation and innate immunity. We previously reported that an activated form of tyrosyl-tRNA synthetase (YRS ACT ) has an extratranslational activity that enhances megakaryop
Autor:
Jennifer G. Nolasco, Leticia H. Nolasco, Qi Da, Sonya Cirlos, Zaverio M. Ruggeri, Joel L. Moake, Miguel A. Cruz
Publikováno v:
TH Open, Vol 02, Iss 03, Pp e338-e345 (2018)
von Willebrand factor (VWF) is a multimeric protein composed of monomeric subunits (∼280 kD) linked by disulfide bonds. During hemostasis and thrombosis, ultralarge (UL) VWF (ULVWF) multimers initiate platelet adhesion. In vitro, human C3 binds to
Externí odkaz:
https://doaj.org/article/3336b2a3967c45acbd64eff286c182c8
Autor:
Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A. Gilad, Thomas S. Kickler, Tobias Obser, Zaverio M. Ruggeri, Joseph Katz
Publikováno v:
International Journal of Biomedical Imaging, Vol 2017 (2017)
Tracking cells and proteins’ phenotypic changes in deep suspensions is critical for the direct imaging of blood-related phenomena in in vitro replica of cardiovascular systems and blood-handling devices. This paper introduces fluorescence imaging t
Externí odkaz:
https://doaj.org/article/bfd9fc4082b840e7be01e1bdacd5e5b1
Autor:
Hagai Tavori, Matthew A. Muller, Zaverio M. Ruggeri, Paul Mueller, Oleg Varlamov, William Packwood, Dominic W. Chung, Jonathan R. Lindner, Koya Ozawa, Aris Xie, José A. López
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • In murine models of atherosclerosis, excess endothelial-associated vWF results not only in platelet adhesion, but also endothelial expression of leukocyte adhesion molecules, indicating a role of platelets in endot
Highlights • In murine models of atherosclerosis, excess endothelial-associated vWF results not only in platelet adhesion, but also endothelial expression of leukocyte adhesion molecules, indicating a role of platelets in endot
Autor:
Roberto Aiolfi, Giovanni Sitia, Matteo Iannacone, Ivan Brunetta, Luca G. Guidotti, Zaverio M. Ruggeri
Publikováno v:
Science Signaling. 15
Bleeding correlates with disease severity in viral hemorrhagic fevers. We found that the increase in type I interferon (IFN-I) in mice caused by infection with the Armstrong strain of lymphocytic choriomeningitis virus (LCMV; an arenavirus) reduced t
Publikováno v:
Blood
Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by antibody-mediated platelet destruction. Different mechanisms have been suggested to explain accelerated platelet clearance and impaired thrombopoiesis, but the pathophysi
Autor:
Zihan Guo, Zaverio M. Ruggeri, Laurent O. Mosnier, Tine Wyseure, Jevgenia Zilberman-Rudenko, Owen J. T. McCarty, Jennifer N. Orje, Tobias Eckle, Yoshimasa Oyama, Hiroshi Deguchi, Meenal Shukla, John H. Griffin
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Cardiac myosin (CM) is structurally similar to skeletal muscle myosin, which has procoagulant activity. Here, we evaluated CM’s ex vivo, in vivo, and in vitro activities related to hemostasis and thrombosis. Approach and Results: Perfusi