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Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents.

Autor: Sapozhnikova TA; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation. Electronic address: newpharm@anrb.ru., Borisevich SS; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Kireeva DR; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Gabdrakhmanova SF; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Khisamutdinova RY; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Makara NS; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Gibadullina NN; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Khursan SL; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation., Zarudii FS; Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation; FSBEI HE Bashkir State Medical University MOH Russia, Department of Pharmacology, 450000, Ufa, Lenin str., 3, Russian Federation.

Publikováno v: Behavioural brain research [Behav Brain Res] 2019 Nov 05; Vol. 373, pp. 112109. Date of Electronic Publication: 2019 Jul 21.

Nootropic Activity of a Novel (-)-Cytisine Derivative (3aR,4S,8S,12R, 12aS,12bR)-10-Methyl-2-Phenyloctahydro-1H-4,12a-Etheno-8,12-Methanopyrrolo[3',4':3,4]Pyrido[1,2-a] [1,5]Diazocine-1,3,5(4H)-Trione.

Autor: Makara NS; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia. newpharm@anrb.ru., Sapozhnikova TA; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Khisamutdinova RY; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Tsypysheva IP; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Borisevich SS; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Kovalskaya AV; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Petrova PR; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Khursan CL; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia., Zarudii FS; Laboratory of Bioorganic Chemistry and Catalysis, Ufa Institute of Chemistry, Russian Academy of Sciences, Ufa, Russia.; Department of Pharmacology No. 1, Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, Russia.

Publikováno v: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Mar; Vol. 164 (4), pp. 434-438. Date of Electronic Publication: 2018 Mar 03.