Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

Autor: Zarmeena Abid, Mette Dalskov Mosgaard, Giorgio Manfroni, Ritika Singh Petersen, Line Hagner Nielsen, Anette Müllertz, Anja Boisen, Stephan Sylvest Keller

Publikováno v: Polymers, Vol 11, Iss 11, p 1828 (2019)

Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainer

Externí odkaz: https://doaj.org/article/48fa1370ff8e4763887273caf252c71c

Biodegradable microcontainers – towards real life applications of microfabricated systems for oral drug delivery

Autor: Zarmeena Abid, Stephan Sylvest Keller, Line Hagner Nielsen, Carsten Gundlach, Madeeha M. Javed, Chiara Mazzoni, Ritika Singh Petersen, Anja Boisen, Sophie Strindberg, Anette Müllertz, Lukas Vaut

Publikováno v: Abid, Z, Strindberg, S, Javed, M M, Mazzoni, C, Vaut, L, Nielsen, L H, Gundlach, C, Petersen, R S, Müllertz, A, Boisen, A & Keller, S S 2019, ' Biodegradable microcontainers-towards real life applications of microfabricated systems for oral drug delivery ', Lab on a Chip, vol. 19, pp. 2905-2914 . https://doi.org/10.1039/c9lc00527g
Abid, Z, Strindberg, S, Javed, M M, Mazzoni, C, Vaut, L, Nielsen, L H, Gundlach, C, Petersen, R S, Müllertz, A, Boisen, A & Keller, S S 2019, ' Biodegradable microcontainers-towards real life applications of microfabricated systems for oral drug delivery ', Lab on a Chip, vol. 19, no. 17, pp. 2905-2914 . https://doi.org/10.1039/c9lc00527g

Microfabrication techniques have been applied to develop micron-scale devices for oral drug delivery with a high degree of control over size, shape and material composition. Recently, microcontainers have been introduced as a novel approach to obtain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e77fbf6432dc077a77901bbc285bc0
https://doi.org/10.1039/c9lc00527g

Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

Autor: Ritika Singh Petersen, Anja Boisen, Anette Müllertz, Stephan Sylvest Keller, Mette Dalskov Mosgaard, Zarmeena Abid, Line Hagner Nielsen, Giorgio Manfroni

Publikováno v: Abid, Z, Dalskov Mosgaard, M, Manfroni, G, Singh Petersen, R, Hagner Nielsen, L, Mullertz, A, Boisen, A & Sylvest Keller, S 2019, ' Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery ', Polymers, vol. 11, 1828 . https://doi.org/10.3390/polym11111828
Polymers, Vol 11, Iss 11, p 1828 (2019)
Polymers
Volume 11
Issue 11
Abid, Z, Mosgaard, M D, Manfroni, G, Petersen, R S, Nielsen, L H, Müllertz, A, Boisen, A & Keller, S S 2019, ' Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery ', Polymers, vol. 11, 1828 . https://doi.org/10.3390/polym11111828

Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b366d6830506796a3b5f4338980850c8
https://doi.org/10.3390/polym11111828

Single step fabrication and loading of biopolymer microcontainers for oral drug delivery

Autor: Zarmeena Abid, Ritika Petersen, Anja Boisen, Stephan Sylvest Keller

Publikováno v: Abid, Z, Petersen, R S, Boisen, A & Keller, S S 2017, ' Single step fabrication and loading of biopolymer microcontainers for oral drug delivery ', 43rd International conference on Micro and Nano Engineering, Braga, Portugal, 18/09/2017-22/09/2017 .
Technical University of Denmark Orbit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4c82708cd8d5f8a720b7963da7175dfc
https://orbit.dtu.dk/en/publications/25ad01fa-b83a-46cf-aedd-917f3ba41f22

Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers

Autor: Stephan Sylvest Keller, Mette Dalskov Mosgaard, Zarmeena Abid, Anette Müllertz, Lasse Højlund Thamdrup, Alina Joukainen Andersen, Ritika Singh Petersen, Line Hagner Nielsen, Sophie Strindberg, Anja Boisen

Publikováno v: Mosgaard, M D, Strindberg, S, Abid, Z, Petersen, R S, Thamdrup, L H E, Andersen, A J, Keller, S S, Müllertz, A, Nielsen, L H & Boisen, A 2019, ' Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers ', International Journal of Pharmaceutics, vol. 570, 118658 . https://doi.org/10.1016/j.ijpharm.2019.118658
Dalskov Mosgaard, M, Strindberg, S, Abid, Z, Singh Petersen, R, Højlund Eklund Thamdrup, L, Joukainen Andersen, A, Sylvest Keller, S, Müllertz, A, Hagner Nielsen, L & Boisen, A 2019, ' Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers ', International Journal of Pharmaceutics, vol. 570, 118658 . https://doi.org/10.1016/j.ijpharm.2019.118658

Micro fabricated delivery systems have shown promise in increasing oral bioavailability of drugs. Micrometer-sized polymeric devices (microcontainers) have the potential to facilitate unidirectional drug release directly into the intestinal mucosa wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e726535a84ff6d996d6d1e45e540c1
https://doi.org/10.1016/j.ijpharm.2019.118658