An in vitro assay for toxicity testing of Clostridium perfringens type C β-toxin

Autor: Marieke Hoonakker, Afshin Zariri, Lisette de Brouwer, Dionne David, Anouska Borgman, Arjen Sloots

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionVeterinary vaccines against Clostridium perfringens type C need to be tested for absence of toxicity, as mandated by pharmacopoeias worldwide. This toxicity testing is required at multiple manufacturing steps and relies on outdated mouse

Externí odkaz: https://doaj.org/article/2eaa5964b3c24348a59f7e8709fb8d23

An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection

Autor: Peter A. van der Ley, Afshin Zariri, Elly van Riet, Dinja Oosterhoff, Corine P. Kruiswijk

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The development of more effective, accessible, and easy to administer COVID-19 vaccines next to the currently marketed mRNA, viral vector, and whole inactivated virus vaccines is essential to curtailing the SARS-CoV-2 pandemic. A major concern is red

Externí odkaz: https://doaj.org/article/4a08266b267a4ae9a3b63ffe4959efd8

Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity

Autor: Jesús Arenas, Elder Pupo, Coen Phielix, Dionne David, Afshin Zariri, Alla Zamyatina, Jan Tommassen, Peter van der Ley

Publikováno v: Vaccines, Vol 8, Iss 4, p 594 (2020)

Whooping cough, or pertussis, is an acute respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis. Whole-cell vaccines, which were introduced in the fifties of the previous century and proved to be effective, showed

Externí odkaz: https://doaj.org/article/20bfbbe2c0ae4a96b351122682a80f4b

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Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity

Autor: Arenas, Jesús, Pupo, Elder, Phielix, Coen, David, Dionne, Zariri, Afshin, Zamyatina, Alla, Tommassen, Jan, Van Der Ley, Peter, Sub Molecular Microbiology, LS Infectiebiologie (Bacteriologie), Molecular Microbiology

Publikováno v: Vaccines, Vol 8, Iss 594, p 594 (2020)
Vaccines
Volume 8
Issue 4
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Consejo Superior de Investigaciones Científicas (CSIC)
Vaccines, 8(4). Multidisciplinary Digital Publishing Institute
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

Whooping cough, or pertussis, is an acute respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis. Whole-cell vaccines, which were introduced in the fifties of the previous century and proved to be effective, showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4db51e4f92117401e07c6d8add2d4dc
https://hdl.handle.net/1874/410335