Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Zarin Tabassum"'
Autor:
Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.
Externí odkaz:
https://doaj.org/article/61ab6286279144ac8d59a59cc0805267
Publikováno v:
The FASEB Journal. 36
Autor:
Ashutosh Tripathy, Deepa Ajit, Natallia V. Riddick, John Q. Trojanowski, Michelle S. Itano, Sheryl S. Moy, Hanna Trzeciakiewicz, Todd J. Cohen, Zarin Tabassum, Youjun Chen, Claire Peterson, Rebecca Lobrovich, Jui-Heng Tseng, Aditi Ajit, Virginia M.-Y. Lee, David J. Irwin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates ta
Autor:
Zarin Tabassum, Jui-Heng Tseng, Camryn Isemann, Xu Tian, Youjun Chen, Laura E. Herring, Todd J. Cohen
Publikováno v:
The Journal of biological chemistry. 298(6)
The posttranslational regulation of the neuronal proteome is critical for brain homeostasis but becomes dysregulated in the aged or diseased brain, in which abnormal posttranslational modifications (PTMs) are frequently observed. While the full exten
Autor:
Zarin Tabassum1, Jui-Heng Tseng1, Isemann, Camryn1, Xu Tian1, Youjun Chen1, Herring, Laura E.2, Cohen, Todd J.1,3 toddcohen@neurology.unc.edu
Publikováno v:
Journal of Biological Chemistry. Jun2022, Vol. 298 Issue 6, p1-14. 14p.
Autor:
Youjun Chen, Xu Tian, Frank Rigo, Alex W. Prevatte, Todd J. Cohen, Karen Ling, Jui-Heng Tseng, Zarin Tabassum, Aditi Ajit, Rick B. Meeker, Niyati Patel, Laura E. Herring
Publikováno v:
SSRN Electronic Journal.
The prion-like spread of tau pathology could underlie a spectrum of distinct clinical syndromes including Alzheimer’s disease (AD). Although evidence indicates that tau is transmissible, it is unclear how pathogenic tau species evolve in neurons. H
Autor:
Karen Ling, Youjun Chen, Jui-Heng Tseng, Aditi Ajit, Rick B. Meeker, Alex W. Prevatte, Frank Rigo, Niyati Patel, Xu Tian, Laura E. Herring, Zarin Tabassum, Todd J. Cohen
Publikováno v:
Cell Rep
Summary The prion-like spread of tau pathology could underlie a spectrum of clinical syndromes including Alzheimer’s disease (AD). Although evidence indicates that tau is transmissible, it is unclear how pathogenic tau seeds are processed in neuron
Publikováno v:
2018 3rd International Conference for Convergence in Technology (I2CT).
This paper analyzes & compares four adders with different logic styles (Conventional, transmission gate, 14 transistors & GDI based technique) for transistor count, power dissipation, delay and power delay product. It is performed in virtuoso platfor