Gut microbial composition mediates the relationship between intestinal inflammation and amyloid burden before cognitive decline.

Autor: Heston, Margo B., Hong, Qilin, González, Antonio, Betthauser, Tobey J, Chin, Nathaniel A., Hanslik, Kendra L., Zarbock, Katie R, Kerby, Robert L., Asthana, Sanjay, Johnson, Sterling C, Knight, Rob, Kaddurah‐Daouk, Rima F., Tang, ZhengZheng, Ulland, Tyler K., Rey, Federico E., Bendlin, Barbara B

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 13, Vol. 19, p1-4, 4p

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Gut inflammation associated with age and Alzheimer's disease pathology: a human cohort study.

Autor: Heston MB; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Hanslik KL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA., Zarbock KR; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA., Harding SJ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Davenport-Sis NJ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Kerby RL; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA., Chin N; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Sun Y; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA., Hoeft A; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Deming Y; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Vogt NM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Betthauser TJ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Wild N; Roche Diagnostics GmbH, Penzberg, Germany., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. ferey@wisc.edu., Bendlin BB; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. bbb@medicine.wisc.edu.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. bbb@medicine.wisc.edu., Ulland TK; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. tulland@wisc.edu.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA. tulland@wisc.edu.

Publikováno v: Scientific reports [Sci Rep] 2023 Nov 14; Vol. 13 (1), pp. 18924. Date of Electronic Publication: 2023 Nov 14.