Výsledky vyhledávání - "Zara J Franklin"

Akademický článek

Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

Autor: Luis Fernando Delgadillo-Silva, Anastasia Tsakmaki, Nadeem Akhtar, Zara J. Franklin, Judith Konantz, Gavin A. Bewick, Nikolay Ninov

Publikováno v: Disease Models & Mechanisms, Vol 12, Iss 1 (2019)

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap require

Externí odkaz: https://doaj.org/article/7f5ba0f044434aa0811b586038338678

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Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

Autor: Ryan A Lafferty, Laura M McShane, Zara J Franklin, Peter R Flatt, Finbarr P M O’Harte, Nigel Irwin

Publikováno v: The Journal of endocrinology. 255(2)

Discerning modification to the amino acid sequence of native glucagon can generate specific glucagon receptor (GCGR) antagonists, that include desHis1Pro4Glu9-glucagon and the acylated form desHis1Pro4Glu9(Lys12PAL)-glucagon. In the current study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c08cd0719f2e35806e770371c4b66e1
https://pubmed.ncbi.nlm.nih.gov/36005280

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Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta-cell mass

Autor: Zara J. Franklin, Patricia Fonseca Pedro, Shanta J. Persaud, Guo Cai Huang, Aileen King, Gavin A. Bewick, Anastasia Tsakmaki, Sakeena Amjad

Publikováno v: Franklin, Z J, Tsakmaki, A, Fonseca Pedro, P, King, A J, Huang, G C, Amjad, S, Persaud, S J & Bewick, G A 2017, ' Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta-cell mass ', Diabetes, obesity & metabolism . https://doi.org/10.1111/dom.13119

Aims: Two unmet therapeutic strategies for diabetes treatment are prevention of beta-cell death and stimulation of beta-cell replication. Our aim was to characterize the role of neuropeptide Y receptors in the control of beta-cell mass. Materials and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aaa8593d719b6b77a674027df7b2e8
https://doi.org/10.1111/dom.13119

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Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction

Autor: Pratik Choudhary, Astrid C Hauge-Evans, Guo Cai Huang, Bo Liu, Peter M. Jones, Zara J. Franklin, Shanta J. Persaud, Alonso Vilches-Flores

Publikováno v: BBA Clinical
Vilches-Flores, A, Franklin, Z, Hauge-Evans, A C, Liu, B, Huang, G C, Choudhary, P, Jones, P M & Persaud, S J 2016, ' Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction ', BBA Clinical . https://doi.org/10.1016/j.bbacli.2016.03.009

Background Although in vivo studies have implicated endocannabinoids in metabolic dysfunction, little is known about direct, chronic activation of the endocannabinoid system (ECS) in human islets. Therefore, this study investigated the effects of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc8f320c2624463eeb8f77c812f8dec
http://europepmc.org/articles/PMC4832123

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Inhibitory effect of somatostatin on insulin secretion is not mediated via the CNS

Autor: Zara J. Franklin, Astrid C Hauge-Evans, James E. Bowe, Zoheb Hassan, Peter M. Jones

Publikováno v: Journal of Endocrinology. 225:19-26

The inhibitory effect of somatostatin (SST) on insulin secretionin vivois attributed to a direct effect on pancreatic beta cells, but this is inconsistent with somein vitroresults in which exogenous SST is ineffective in inhibiting secretion from iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a649adf421e21069028da0f829a0176e
https://doi.org/10.1530/joe-14-0709

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Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets

Autor: Aileen King, Stefan Amisten, Astrid C Hauge-Evans, Zara J. Franklin, Alonso Vilches-Flores, Christina Reers, Alan Kerby, Shanta J. Persaud, Peter M. Jones, Z Tippu, Zoheb Hassan

Publikováno v: Diabetes, Obesity and Metabolism. 16:947-956

Aims Islets are innervated by parasympathetic nerves which release acetylcholine (ACh) to amplify glucose-induced insulin secretion, primarily via muscarinic M3 receptors (M3R). Here we investigate the consequence of chronic hyperglycaemia on islet M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2547bd62e9b92d922b1d2098dff0de
https://doi.org/10.1111/dom.12301

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Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Autor: Zara J. Franklin, Nigel Irwin, Finbarr O'Harte, EP Rafferty

Publikováno v: Molecular and Cellular Endocrinology. 381:26-34

Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis(1)Pro(4)-glucagon, desHis(1)Pro(4)Glu(9)-glucagon, desHis(1)Pro(4)Glu(9)Lys(12)FA-glucagon and desHis(1)Pro(4)Glu(9)Lys(30)FA-glucagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc556a0ba1dd80a79a1ebaa37b81128
https://doi.org/10.1016/j.mce.2013.07.014

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Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

Autor: Zara J. Franklin, Nigel Irwin, Finbarr O'Harte

Publikováno v: Biological Chemistry. 395:433-442

Glucagon is a hormone with important effects on blood glucose regulation. This study has utilized the stable glucagon receptor antagonists, desHis1Pro4Glu9-glucagon and desHis1Pro4Glu9(Lys12PAL)-glucagon, to evaluate the effects of sustained inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24582eb291748704810d89dc1facf66a
https://doi.org/10.1515/hsz-2013-0224

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Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice

Autor: Zara J. Franklin, Nigel Irwin, Finbarr O'Harte, D O'Flynn, Laura McShane, Chandralal M. Hewage

Publikováno v: JOURNAL OF ENDOCRINOLOGY

Ablation of glucagon receptor signaling represents a potential treatment option for type 2 diabetes (T2DM). Additionally, activation of glucose-dependent insulinotropic polypeptide (GIP) receptor signaling also holds therapeutic promise for T2DM. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754f19b106f4c5b90da88d443bd5ce21

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