Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zaofeng Yang"'
Autor:
Wenxiu Zhang, Zaofeng Yang, Jiale Zheng, Kaili Fu, Jack Ho Wong, Yunbi Ni, Tzi Bun Ng, Chi Hin Cho, Michael K. Chan, Marianne M. Lee
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Helicobacter pylori (H. pylori) causes infection in the stomach and is a major factor for gastric carcinogenesis. The application of antimicrobial peptides (AMPs) as an alternative treatment to traditional antibiotics is limited by their fac
Externí odkaz:
https://doaj.org/article/20d543b4651740d89077bc1f831a2647
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Although immune checkpoint inhibitors (ICIs) have been shown to yield promising therapeutic outcomes in a small subset of patients with triple negative breast cancer (TNBC), the majority of patients either do not respond or subsequently de
Externí odkaz:
https://doaj.org/article/5dc74c03c0024904801f2397e4b72253
Autor:
Zaofeng Yang, Bradley S. Heater, Clayton T. Cuddington, Andre F. Palmer, Marianne M.M. Lee, Michael K. Chan
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101158- (2020)
Summary: The effectiveness of cancer radiotherapy is frequently hindered by the hypoxia of the tumor microenvironment. Direct delivery of oxygen to hypoxic tumor tissues is an attractive strategy to overcome this hypoxia-associated radioresistance. H
Externí odkaz:
https://doaj.org/article/3f8d2c60168d45ba8c95bcbcbaf3b784
Publikováno v:
Acta Biomaterialia. 135:582-592
The tumor suppressor p16 protein is an endogenous CDK4/6 inhibitor. Inactivation of its encoding gene is found in nearly half of human cancers. Restoration of p16 function via adenovirus-based gene delivery has been shown to be effective in suppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d10a563f1eff2fafb73bbdb5dc2573
https://doi.org/10.1016/j.actbio.2021.08.054
https://doi.org/10.1016/j.actbio.2021.08.054
Publikováno v:
Journal of the American Chemical Society. 142:9879-9883
Cry3Aa is a protein that forms crystals naturally in the bacterium Bacillus thuringiensis. Here we report that coexpression of Cry3Aa and a Proteus mirabilis lipase without recombinant fusion results in the efficient passive entrapment of the lipase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce96982fcd0d9ba71f01d29db903326
https://doi.org/10.1021/jacs.9b13462
https://doi.org/10.1021/jacs.9b13462
Autor:
Michael K. Chan, Jiale Zheng, Marianne M. Lee, Zhen Liu, Tak Hang Chan, Zaofeng Yang, Iris L. K. Wong, Larry M.C. Chow, Chin Fung Chan, Xianliang Zhao
Publikováno v:
Antimicrob Agents Chemother
We have designed, synthesized, and characterized a library of 38 novel flavonoid compounds linked with amines. Some of these amine-linked flavonoids have potent in vitro activity against parasites that cause cutaneous leishmaniasis, a tropical diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1dfb6e24f4e2b298f6ae3a1abd42f6
https://europepmc.org/articles/PMC8092861/
https://europepmc.org/articles/PMC8092861/
Publikováno v:
Biomaterials. 271:120759
Direct delivery of proteins into cells holds significant potential for basic research and drug development. However, the poor endosomal escape of conventional delivery strategies remains a challenge, thus limiting the clinical translation of many pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ab66c728aaa5ae64b7e5547e0735e9
https://doi.org/10.1016/j.biomaterials.2021.120759
https://doi.org/10.1016/j.biomaterials.2021.120759
Autor:
Marianne M. Lee, Andre F. Palmer, Zaofeng Yang, Clayton T. Cuddington, Bradley S. Heater, Michael K. Chan
Publikováno v:
iScience
iScience, Vol 23, Iss 6, Pp 101158-(2020)
iScience, Vol 23, Iss 6, Pp 101158-(2020)
Summary The effectiveness of cancer radiotherapy is frequently hindered by the hypoxia of the tumor microenvironment. Direct delivery of oxygen to hypoxic tumor tissues is an attractive strategy to overcome this hypoxia-associated radioresistance. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a464b2fa33a6e6e6a2d0fbaf275dd462
https://doi.org/10.1016/j.isci.2020.101158
https://doi.org/10.1016/j.isci.2020.101158
Publikováno v:
Journal of molecular histology. 49(4)
Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5b11d4896b14fc2ca099eb58f6742f
https://pubmed.ncbi.nlm.nih.gov/29916090
https://pubmed.ncbi.nlm.nih.gov/29916090
Targeted delivery of antimicrobial peptide by Cry protein crystal to treat intramacrophage infection
Autor:
Marianne M. Lee, Iris L. K. Wong, Jiale Zheng, Zaofeng Yang, Larry M.C. Chow, Bradley S. Heater, Michael K. Chan, Chin-Fung Chan
Publikováno v:
Biomaterials. 217:119286
Antimicrobial peptides (AMPs) have recently attracted great attention due to their rapid action, broad spectrum of activity, and low propensity of resistance development. The successful application of AMPs in the treatment of intracellular infections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299587004d97a35869648d601f21cc36
https://doi.org/10.1016/j.biomaterials.2019.119286
https://doi.org/10.1016/j.biomaterials.2019.119286