Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Autor: Van Haver, Stéphane, Fan, Yujie, Bekaert, Sarah-Lee, Everaert, Celine, Van Loocke, Wouter, Zanzani, Vittorio, Deschildre, Joke, Maestre, Inés Fernandez, Amaro, Adrianna, Vermeirssen, Vanessa, De Preter, Katleen, Zhou, Ting, Kentsis, Alex, Studer, Lorenz, Speleman, Frank, Roberts, Stephen S.

Publikováno v: In iScience 19 January 2024 27(1)

Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma.

Autor: Van Haver S; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium., Fan Y; The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Developmental Biology Program, MSKCC, New York, NY 10065, USA.; Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10065, USA., Bekaert SL; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium., Everaert C; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium., Van Loocke W; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium., Zanzani V; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Lab for Computational Biology, Integromics and Gene Regulation (CBIGR), Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium., Deschildre J; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Lab for Computational Biology, Integromics and Gene Regulation (CBIGR), Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium., Maestre IF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Amaro A; Department of Pediatrics, MSKCC, New York, NY 10065, USA., Vermeirssen V; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Lab for Computational Biology, Integromics and Gene Regulation (CBIGR), Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium., De Preter K; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium., Zhou T; The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA., Kentsis A; Department of Pediatrics, MSKCC, New York, NY 10065, USA.; Molecular Pharmacology Program, MSKCC, New York, NY, USA.; Tow Center for Developmental Oncology, MSKCC, New York, NY 10065, USA.; Departments of Pediatrics, Pharmacology and Physiology & Biophysics, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA., Studer L; The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Developmental Biology Program, MSKCC, New York, NY 10065, USA., Speleman F; Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium., Roberts SS; Department of Pediatrics, MSKCC, New York, NY 10065, USA.

Publikováno v: IScience [iScience] 2023 Sep 30; Vol. 27 (1), pp. 108096. Date of Electronic Publication: 2023 Sep 30 (Print Publication: 2024).