Výsledky vyhledávání - "Zaneta D Musimbi"

Akademický článek

Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs

Autor: Robert M. Mugo, Larissa Oser, Ankur Midha, Joshua Adjah, Arkadi Kundik, Alexandra Laubschat, Philipp Höfler, Zaneta D. Musimbi, Rima Hayani, Josephine Schlosser-Brandenburg, Susanne Hartmann, Sebastian Rausch

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Natural killer (NK) cells play a key role in defense against Salmonella infections during the early phase of infection. Our previous work showed that the excretory/secretory products of Ascaris suum repressed NK activity in vitro. Here, we a

Externí odkaz: https://doaj.org/article/3179835dfd614f148a2a73389efd8278

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Akademický článek

Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs

Autor: Ankur Midha, Larissa Oser, Josephine Schlosser-Brandenburg, Alexandra Laubschat, Robert M. Mugo, Zaneta D. Musimbi, Philipp Höfler, Arkadi Kundik, Rima Hayani, Joshua Adjah, Saskia Groenhagen, Malte Tieke, Luis E. Elizalde-Velázquez, Anja A. Kühl, Robert Klopfleisch, Karsten Tedin, Sebastian Rausch, Susanne Hartmann

Publikováno v: mSphere, Vol 9, Iss 9 (2024)

ABSTRACT Ascaris is one of the most widespread helminth infections, leading to chronic morbidity in humans and considerable economic losses in pig farming. In addition, pigs are an important reservoir for the zoonotic salmonellosis, where pigs can se

Externí odkaz: https://doaj.org/article/98244c79ce29447698b26323f2819a17

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Akademický článek

Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings.

Autor: Robert M Mugo, Sebastian Rausch, Zaneta D Musimbi, Christina Strube, Marie-Kristin Raulf, Olfert Landt, Paul M Gichuki, Friederike Ebner, Jedidah Mwacharo, Maurice R Odiere, Francis M Ndungu, Doris W Njomo, Susanne Hartmann

Publikováno v: PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012279 (2024)

BackgroundThe standard diagnosis of Ascaris lumbricoides and other soil-transmitted helminth (STH) infections relies on the detection of worm eggs by copromicroscopy. However, this method is dependent on worm patency and shows only limited accuracy i

Externí odkaz: https://doaj.org/article/91077f3cc8424017a2d291e150ef0f27

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Akademický článek

Ascaris suum infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion

Autor: Larissa Oser, Ankur Midha, Josephine Schlosser-Brandenburg, Sebastian Rausch, Robert M. Mugo, Arkadi Kundik, Luis E. Elizalde-Velázquez, Joshua Adjah, Zaneta D. Musimbi, Robert Klopfleisch, Christina S. Helm, Georg von Samson-Himmelstjerna, Susanne Hartmann, Friederike Ebner

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Ascaris spp. undergo extensive migration within the body before establishing patent infections in the small intestinal tract of humans and pigs. However, whether larval migration is critical for inducing efficient type 2 responses remains poorly unde

Externí odkaz: https://doaj.org/article/8008e6abf43b4c25a7d89954bd7bba19

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Akademický článek

Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction

Autor: Arkadi Kundik, Zaneta D. Musimbi, Jürgen Krücken, Thomas Hildebrandt, Oleg Kornilov, Susanne Hartmann, Friederike Ebner

Publikováno v: Parasites & Vectors, Vol 16, Iss 1, Pp 1-13 (2023)

Abstract Background Helminth infections are an important public health problem in humans and have an even greater impact on domestic animal and livestock welfare. Current readouts for anthelmintic drug screening assays are stage development, migratio

Externí odkaz: https://doaj.org/article/3bf7861bab0a45ef95d6cd20080837f2

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