An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration.

Autor: Leventhal MJ; MIT Ph.D. Program in Computational and Systems Biology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zanella CA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kang B; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA., Peng J; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Gritsch D; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Liao Z; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Bukhari H; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wang T; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Present address: School of Computer Science, Northwestern Polytechnical University, Xi'an, China., Pao PC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Danquah S; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Benetatos J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Nehme R; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Farhi S; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA., Tsai LH; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Dong X; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Scherzer CR; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Present address: Stephen and Denise Adams Center of Yale School of Medicine, CT, USA., Feany MB; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Fraenkel E; MIT Ph.D. Program in Computational and Systems Biology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 09. Date of Electronic Publication: 2024 Oct 09.

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies.

Autor: Nazeen S; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Wang X; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Zielinski D; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Whitehead Institute of Biomedical Research, Cambridge, MA, USA., Lam I; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Hallacli E; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Xu P; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ethier E; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Strom R; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Zanella CA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Nithianandam V; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ritter D; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA., Henderson A; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA., Saurat N; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA., Afroz J; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA., Nutter-Upham A; Whitehead Institute of Biomedical Research, Cambridge, MA, USA., Benyamini H; Whitehead Institute of Biomedical Research, Cambridge, MA, USA., Copty J; Garvan Institute of Medical Research, Sydney, NSW, Australia., Ravishankar S; Garvan Institute of Medical Research, Sydney, NSW, Australia., Morrow A; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Mitchel J; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA., Neavin D; Garvan Institute of Medical Research, Sydney, NSW, Australia., Gupta R; Garvan Institute of Medical Research, Sydney, NSW, Australia., Farbehi N; Garvan Institute of Medical Research, Sydney, NSW, Australia., Grundman J; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Myers RH; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Scherzer CR; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Trojanowski JQ; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA., Van Deerlin VM; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA., Cooper AA; Garvan Institute of Medical Research, Sydney, NSW, Australia., Lee EB; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA., Erlich Y; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lindquist S; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Peng J; Department of Computer Science, University of Illinois Urbana-Champaign, Champaign, IL, USA., Geschwind DH; Center for Autism Research and Treatment, Semel Institute, Program in Neurogenetics, Department of Neurology and Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Powell J; Garvan Institute of Medical Research, Sydney, NSW, Australia.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Studer L; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Feany MB; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Sunyaev SR; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Khurana V; Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 07. Date of Electronic Publication: 2024 Mar 07.

A Drosophila model of chemotherapy-related cognitive impairment.

Autor: Torre M; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Bukhari H; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Nithianandam V; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Zanella CA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Mata DA; Foundation Medicine, Inc., Cambridge, MA., Feany MB; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 05. Date of Electronic Publication: 2023 Jun 05.

Guanosine modulates SUMO2/3-ylation in neurons and astrocytes via adenosine receptors.

Autor: Zanella CA; Department of Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., Tasca CI; Department of Biochemistry, UFSC, Florianópolis, SC, Brazil., Henley JM; School of Biochemistry, University of Bristol, Bristol, UK., Wilkinson KA; School of Biochemistry, University of Bristol, Bristol, UK. kevin.wilkinson@bristol.ac.uk., Cimarosti HI; Department of Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil. helena.cimarosti@ufsc.br.

Publikováno v: Purinergic signalling [Purinergic Signal] 2020 Sep; Vol. 16 (3), pp. 439-450. Date of Electronic Publication: 2020 Sep 05.

Sumoylation: Implications for Neurodegenerative Diseases.

Autor: Anderson DB; Ipsen Bioinnovation Ltd, Units 4-10 The Quadrant, Barton Lane, Abingdon, OX14 3YS, UK., Zanella CA; Department of Pharmacology, Federal University of Santa Catarina, Campus Universitario - Trindade, Florianopolis, CEP, 88040-900, Brazil., Henley JM; MRC Centre for Synaptic Plasticity, School of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, UK., Cimarosti H; Department of Pharmacology, Federal University of Santa Catarina, Campus Universitario - Trindade, Florianopolis, CEP, 88040-900, Brazil. helena.cimarosti@ufsc.br.

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2017; Vol. 963, pp. 261-281.