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pro vyhledávání: '"Zane T. Laughlin"'
Autor:
Zane T. Laughlin, Graeme L. Conn
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The tuberactinomycins are a family of cyclic peptide ribosome-targeting antibiotics with a long history of use as essential second-line treatments for drug-resistant tuberculosis. Beginning with the identification of viomycin in the early 1950s, this
Externí odkaz:
https://doaj.org/article/de778e41ab674e82acdd2375e7d82cac
Autor:
Zane T, Laughlin, Suparno, Nandi, Debayan, Dey, Natalia, Zelinskaya, Marta A, Witek, Pooja, Srinivas, Ha An, Nguyen, Emily G, Kuiper, Lindsay R, Comstock, Christine M, Dunham, Graeme L, Conn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(14)
Changes in bacterial ribosomal RNA (rRNA) methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications are typically incorporated by a single methyltransferase that acts on one nucleotide target a