Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Zane R. Hollingsworth"'
Autor:
Clemens R. Scherzer, G.Bernhard Landwehrmeyer, Julie A. Kerner, David G. Standaert, Zane R. Hollingsworth, Lorrie P. Daggett, Gönül Veliçelebi, John B. Penney, Jr., Anne B. Young
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 1, Pp 35-46 (1997)
We have used a quantitativein situhybridization method with human ribonucleotide probes to examine the regional and cellular distribution ofN-methyl-d-aspartate receptor (NMDAR) subunit mRNAs in the human cerebellum. Purkinje cells showed very dense
Externí odkaz:
https://doaj.org/article/d11cc9b8468c40a4a780e439ed95a9e5
Autor:
Richard L.M. Faull, Mauro Delorenzi, Linda Anne Elliston, Doris C. V. Thu, Darlene R. Goldstein, Francois Collin, Andrew D. Strand, Catherine Hartog, Aaron K. Aragaki, Charles Kooperberg, Ruth Luthi-Carter, Sarah J. Augood, James M. Olson, Lesley Jones, Alexandre Kuhn, Peter Holmans, Anne B. Young, Nancy S. Wexler, Zane R. Hollingsworth, Angela Hodges, Beth J. Synek, Gareth Hughes, Thierry Sengstag
Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bdbf86a814ac64fbe03bf038300822
http://doc.rero.ch/record/301565/files/ddl013.pdf
http://doc.rero.ch/record/301565/files/ddl013.pdf
Autor:
David W. Miller, Yoshio A. Kaneko, Anne B. Young, Ruth Luthi-Carter, Steven M. Solano, John B. Penney, Boris S. Spektor, Zane R. Hollingsworth, Jennifer M. Johnson
Publikováno v:
Molecular Brain Research. 102:118-128
The diminished expression of D 1 and D 2 dopamine receptors is a well-documented hallmark of Huntington’s disease (HD), but relatively little is known about how these changes in receptor populations affect the dopaminergic responses of striatal neu
Publikováno v:
The Journal of Comparative Neurology. 421:247-255
The potential role for dopamine in the subthalamic nucleus was investigated in human postmortem tissue sections by examining; (1) immunostaining for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis; (2) binding of [(3)H]-SCH2
Autor:
David R. Borchelt, Stephen J. Tapscott, Ellen B. Penney, James M. Olson, Jang Ho J. Cha, Ruth Luthi-Carter, Ariel S. Frey, Zane R. Hollingsworth, Steven M. Solano, Gabriele Schilling, Nikki L. Peters, Boris S. Spektor, Anil Menon, Christopher A. Ross, Anne B. Young, Andrew D. Strand
Publikováno v:
Human Molecular Genetics. 9:1259-1271
To understand gene expression changes mediated by a polyglutamine repeat expansion in the human huntingtin protein, we used oligonucleotide DNA arrays to profile approximately 6000 striatal mRNAs in the R6/2 mouse, a transgenic Huntington's disease (
Publikováno v:
Brain Research. 773:15-27
Metabotropic glutamate receptors (mGluRs) are thought to mediate diverse processes in brain including synaptic plasticity and excitotoxicity. These receptors are often divided into three groups by their pharmacological profiles. [3H]Glutamate binding
Publikováno v:
Brain Research. 604:354-357
Autoradiography of inhibitory and excitatory amino acid neurotransmitter binding sites in the cervical spinal cord of M. fascicularis spinal cord revealed inhomogeneous distribution of all binding sites in spinal gray matter. Quisqualate-sensitive [3
Publikováno v:
Journal of Neurochemistry. 60:236-245
Exogenous phospholipases have been used extensively as tools to study the role of membrane lipids in receptor mechanisms. We used in vitro quantitative autoradiography to evaluate the effect of phospholipase A2 (PLA2) on N-methyl-D-aspartate (NMDA) a
Autor:
Richard L. Makowiec, Zane R. Hollingsworth, John B. Penney, Leon S. Dure, Anne B. Young, Roger L. Albin
Publikováno v:
Neuroscience. 46:35-48
Quantitative receptor autoradiography was used to determine the distribution of excitatory amino acid binding sites in the basal ganglia of rat brain. alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, N-methyl-D-aspartate, kainate, quisqualat
Autor:
Anne B. Young, Roger L. Albin, Richard L. Makowiec, Zane R. Hollingsworth, Leon S. Dure, John B. Penney
Publikováno v:
Neuroscience Letters. 118:112-115
We used receptor autoradiography to determine the distribution of excitatory amino acid (EAA) binding site subtypes in the periaqueductal gray (PAG) of the rat. N-Methyl-o-aspartate (NMDA), kainate, quisqualate-ionotropic, and quisqualate-metabotropi