Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Zander, Harteveld"'
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Large-scale datasets of protein structures and sequences are becoming ubiquitous in many domains of biological research. Experimental approaches and computational modelling methods are generating biological data at an unprecedente
Externí odkaz:
https://doaj.org/article/16ab3b900365459693ed0478310949fc
Autor:
Pablo Gainza, Sarah Wehrle, Alexandra Van Hall-Beauvais, Anthony Marchand, Andreas Scheck, Zander Harteveld, Stephen Buckley, Dongchun Ni, Shuguang Tan, Freyr Sverrisson, Casper Goverde, Priscilla Turelli, Charlène Raclot, Alexandra Teslenko, Martin Pacesa, Stéphane Rosset, Sandrine Georgeon, Jane Marsden, Aaron Petruzzella, Kefang Liu, Zepeng Xu, Yan Chai, Pu Han, George F. Gao, Elisa Oricchio, Beat Fierz, Didier Trono, Henning Stahlberg, Michael Bronstein, Bruno E. Correia
Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic, and structural data grows. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2dd2d3757cef1923a6c645e8be5972
https://doi.org/10.1101/2022.06.16.496402
https://doi.org/10.1101/2022.06.16.496402
Autor:
Roland Eils, Stéphane Rosset, Andreas Scheck, Jan Mathony, Julius Upmeier zu Belzen, Wei Sun, Bruno E. Correia, Christina Stengl, Sandrine Georgeon, Dominik Niopek, Mareike D. Hoffmann, Sabine Aschenbrenner, Carolin Schmelas, Zander Harteveld, Yanli Wang, Dirk Grimm
Publikováno v:
Nature Chemical Biology. 16:725-730
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633addc7819fcadf4faf5cc3cab783af
https://doi.org/10.1038/s41589-020-0518-9
https://doi.org/10.1038/s41589-020-0518-9
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-13 (2019)
BMC Bioinformatics
BMC Bioinformatics
Background Large-scale datasets of protein structures and sequences are becoming ubiquitous in many domains of biological research. Experimental approaches and computational modelling methods are generating biological data at an unprecedented rate. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adb8b04094ff5e37f55d94bdf0cb0c1
http://link.springer.com/article/10.1186/s12859-019-2796-3
http://link.springer.com/article/10.1186/s12859-019-2796-3
Publikováno v:
The Journal of chemical physics. 154(7)
Computational protein design has emerged as a powerful tool capable of identifying sequences compatible with pre-defined protein structures. The sequence design protocols, implemented in the Rosetta suite, have become widely used in the protein engin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f24e3f0a50394b8a8c3be165ba97ac
https://pubmed.ncbi.nlm.nih.gov/33607903
https://pubmed.ncbi.nlm.nih.gov/33607903
Autor:
Jan Mathony, Bruno E. Correia, Mareike D. Hoffmann, Dominik Niopek, Christina Stengl, Roland Eils, Julius Upmeier zu Belzen, Zander Harteveld
Optogenetic control of CRISPR-Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfd0b3934d582e0d355add8fd46f90f
https://doi.org/10.1101/858589
https://doi.org/10.1101/858589
Autor:
Sabine Aschenbrenner, Bruno E. Correia, Christina Stengl, Zander Harteveld, Jan Mathony, Roland Eils, Stéphane Rosset, Mareike D. Hoffmann, Andreas Scheck, Julius Upmeier zu Belzen, Carolin Schmelas, Dirk Grimm, Dominik Niopek
Anti-CRISPR (Acr) proteins are bacteriophage-derived antagonists of CRISPR-Cas systems. To date, Acrs were obtained either by mining sequence databanks or experimentally screening phage collections, both of which yield a limited repertoire of natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5dd331b3435fe46c584c540a592765
Autor:
Jan, Mathony, Zander, Harteveld, Carolin, Schmelas, Julius, Upmeier Zu Belzen, Sabine, Aschenbrenner, Wei, Sun, Mareike D, Hoffmann, Christina, Stengl, Andreas, Scheck, Sandrine, Georgeon, Stéphane, Rosset, Yanli, Wang, Dirk, Grimm, Roland, Eils, Bruno E, Correia, Dominik, Niopek
Publikováno v:
Nature chemical biology. 16(7)
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b363fb986f645e24595ba4508191463
https://pubmed.ncbi.nlm.nih.gov/32284602
https://pubmed.ncbi.nlm.nih.gov/32284602
Autor:
Julius Upmeier zu Belzen, Bruno E. Correia, Jan Mathony, Dominik Niopek, Christina Stengl, Sabine Aschenbrenner, Mareike D. Hoffmann, Zander Harteveld, Dirk Grimm, Roland Eils
Publikováno v:
Nucleic Acids Research
Optogenetic control of CRISPR–Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe80e09779adc3412e5428ce15f43419
http://europepmc.org/articles/PMC7969004
http://europepmc.org/articles/PMC7969004
MotivationComputational protein design (CPD) calculations rely on the generation of large amounts of data on the search for the best sequences. As such, CPD workflows generally include the batch generation of designed decoys (sampling) followed by ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb2fb55c167b8c5b9a4fd52cfac623c
https://doi.org/10.1101/428045
https://doi.org/10.1101/428045