Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.

Autor: McPherson RC; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Konkel JE; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Prendergast CT; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Thomson JP; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Ottaviano R; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Leech MD; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Kay O; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Zandee SE; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Sweenie CH; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Wraith DC; Department of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Meehan RR; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Drake AJ; University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Anderton SM; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.

Publikováno v: ELife [Elife] 2014 Dec 29; Vol. 3. Date of Electronic Publication: 2014 Dec 29.