α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease.

Autor: Geibl FF; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany.; Department of Psychiatry and Psychotherapy, Philipps University Marburg, 35043, Marburg, Germany., Henrich MT; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany.; Department of Psychiatry and Psychotherapy, Philipps University Marburg, 35043, Marburg, Germany., Xie Z; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Zampese E; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, US., Ueda J; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Tkatch T; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, US., Wokosin DL; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Nasiri E; Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany.; Department of Psychiatry and Psychotherapy, Philipps University Marburg, 35043, Marburg, Germany., Grotmann CA; Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany.; Department of Psychiatry and Psychotherapy, Philipps University Marburg, 35043, Marburg, Germany., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, US., Chandel NS; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Oertel WH; Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. j-surmeier@northwestern.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, US. j-surmeier@northwestern.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2024 Oct 08; Vol. 19 (1), pp. 69. Date of Electronic Publication: 2024 Oct 08.

Feed-forward metabotropic signaling by Cav1 Ca ²⁺ channels supports pacemaking in pedunculopontine cholinergic neurons.

Autor: Tubert C, Zampese E, Pancani T, Tkatch T, Surmeier DJ

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 07. Date of Electronic Publication: 2023 Aug 07.

Ca ²⁺ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons.

Autor: Zampese E; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Wokosin DL; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Gonzalez-Rodriguez P; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Guzman JN; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Tkatch T; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Kondapalli J; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Surmeier WC; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., D'Alessandro KB; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., De Stefani D; Department of Biomedical Sciences, University of Padova, Padova 35131, Italy., Rizzuto R; Department of Biomedical Sciences, University of Padova, Padova 35131, Italy., Iino M; Department of Physiology, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan., Molkentin JD; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA., Chandel NS; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Schumacker PT; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.

Publikováno v: Science advances [Sci Adv] 2022 Sep 30; Vol. 8 (39), pp. eabp8701. Date of Electronic Publication: 2022 Sep 30.

Disruption of mitochondrial complex I induces progressive parkinsonism.

Autor: González-Rodríguez P; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Zampese E; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Stout KA; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Guzman JN; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Ilijic E; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Yang B; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Tkatch T; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Stavarache MA; Department of Neurological Surgery, Weill Cornell Medical College, New York, NY, USA., Wokosin DL; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Gao L; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/ Universidad de Sevilla and CIBERNED, Seville, Spain., Kaplitt MG; Department of Neurological Surgery, Weill Cornell Medical College, New York, NY, USA., López-Barneo J; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/ Universidad de Sevilla and CIBERNED, Seville, Spain., Schumacker PT; Department of Pediatrics, Northwestern University, Chicago, IL, USA., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. j-surmeier@northwestern.edu.

Publikováno v: Nature [Nature] 2021 Nov; Vol. 599 (7886), pp. 650-656. Date of Electronic Publication: 2021 Nov 03.

Genetic association between mitochondrial DNA copy number and glioma risk: insights from causality.

Autor: He, Qiang¹ (AUTHOR), Wang, Wenjing² (AUTHOR), Xu, Dingkang³ (AUTHOR), Xiong, Yang⁴ (AUTHOR), Tao, Chuanyuan¹ (AUTHOR), Ma, Lu¹ (AUTHOR), Ma, Junpeng¹ (AUTHOR), Zheng, Songping¹ (AUTHOR), You, Chao¹ (AUTHOR), Zan, Xin¹ (AUTHOR) xinzan16@126.com

Publikováno v: BMC Cancer. 11/21/2024, Vol. 24 Issue 1, p1-7. 7p.