miR-7 is recruited to the high molecular weight RNA-induced silencing complex in CD8 ⁺ T cells upon activation and suppresses IL-2 signaling.

Autor: Toivakka M; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom., Gordon K; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom., Kumar S; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom., Bermudez-Barrientos JR; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom., Abreu-Goodger C; Institute of Ecology & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom., Zamoyska R; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom Rose.Zamoyska@ed.ac.uk a.buck@ed.ac.uk., Buck AH; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom Rose.Zamoyska@ed.ac.uk a.buck@ed.ac.uk.

Publikováno v: RNA (New York, N.Y.) [RNA] 2023 Dec 18; Vol. 30 (1), pp. 26-36. Date of Electronic Publication: 2023 Dec 18.

Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.

Autor: Tanaka A; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.; Department of Frontier Research in Tumor Immunology, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Osaka, Japan., Maeda S; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Nomura T; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Llamas-Covarrubias MA; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.; Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico., Tanaka S; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Jin L; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Lim EL; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Morikawa H; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Kitagawa Y; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Akizuki S; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Ito Y; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Fujimori C; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Hirota K; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Murase T; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Hashimoto M; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Higo J; Institute for Protein Research, Osaka University, Suita, Japan., Zamoyska R; Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh, UK., Ueda R; Department of Tumor Immunology, Aichi Medical University School of Medicine, Aichi, Japan., Standley DM; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Sakaguchi N; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan., Sakaguchi S; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Feb 06; Vol. 220 (2). Date of Electronic Publication: 2022 Dec 01.

Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis

Autor: Salmond, RJ, Brownlie, RJ, Zamoyska, R

Publikováno v: Cell Cycle
Salmond, R J, Brownlie, R J & Zamoyska, R 2015, ' Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis ', Cell Cycle, vol. 14, no. 5, pp. 705-11 . https://doi.org/10.1080/15384101.2015.1007018

The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene are important risk alleles in human autoimmune diseases. We recently reported that a key phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3d58d5560c267e6ab719f0d6090810ba
http://europepmc.org/articles/PMC4671365

Regulation of autoimmune and anti‐tumour T‐cell responses by PTPN22

Autor: Brownlie, RJ, Zamoyska, R, Salmond, RJ

A number of polymorphisms in immune‐regulatory genes have been identified as risk factors for the development of autoimmune disease. PTPN22 (that encodes a tyrosine phosphatase) has been associated with the development of several autoimmune disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9d89056d1147d115e89863a6f0451944

Pan-cancer analysis of oncogenic role of CEP55 and experiment validation in clear cell renal cell carcinoma.

Autor: zhou, Libin^1,2 (AUTHOR), Zhu, Yimeng³ (AUTHOR), Guo, Fei⁴ (AUTHOR), Long, Huimin^1,2 (AUTHOR) lhllonghuimin@nbu.edu.cn, Yin, Min^1,2 (AUTHOR) lhlyinmin@nbu.edu.cn

Publikováno v: Scientific Reports. 11/16/2024, Vol. 14 Issue 1, p1-15. 15p.