Lytic bacteriophages interact with respiratory epithelial cells and induce the secretion of antiviral and proinflammatory cytokines.

Autor: Zamora PF; Department of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, NH., Reidy TG; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA., Armbruster CR; Department of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, NH.; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA., Sun M; Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA., Van Tyne D; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Turner PE; Center for Phage Biology and Therapy, Yale University, New Haven, CT., Koff JL; Center for Phage Biology and Therapy, Yale University, New Haven, CT., Bomberger JM; Department of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, NH.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 06. Date of Electronic Publication: 2024 Feb 06.

Adaptation and genomic erosion in fragmented Pseudomonas aeruginosa populations in the sinuses of people with cystic fibrosis.

Autor: Armbruster CR; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Marshall CW; Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA., Garber AI; Biodesign Center for Mechanisms of Evolution and School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA., Melvin JA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Zemke AC; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Moore J; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA., Zamora PF; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Li K; Center for Medicine and the Microbiome, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA., Fritz IL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Manko CD; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Weaver ML; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Gaston JR; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Morris A; Center for Medicine and the Microbiome, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA., Methé B; Center for Medicine and the Microbiome, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA., DePas WH; Department of Pediatrics, Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Lee SE; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA. Electronic address: slee192@bwh.harvard.edu., Cooper VS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Center for Medicine and the Microbiome, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA; Pittsburgh Center for Evolutionary Biology & Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: vaughn.cooper@pitt.edu., Bomberger JM; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: jbomb@pitt.edu.

Publikováno v: Cell reports [Cell Rep] 2021 Oct 19; Vol. 37 (3), pp. 109829.

A modified lysosomal organelle mediates nonlytic egress of reovirus.

Autor: Fernández de Castro I; Cell Structure Laboratory, National Center for Biotechnology, Spanish National Research Council, Madrid, Spain., Tenorio R; Cell Structure Laboratory, National Center for Biotechnology, Spanish National Research Council, Madrid, Spain., Ortega-González P; Cell Structure Laboratory, National Center for Biotechnology, Spanish National Research Council, Madrid, Spain., Knowlton JJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Zamora PF; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Lee CH; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA., Fernández JJ; Department of Macromolecular Structures, National Center for Biotechnology, Spanish National Research Council, Madrid, Spain., Dermody TS; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA., Risco C; Cell Structure Laboratory, National Center for Biotechnology, Spanish National Research Council, Madrid, Spain.

Publikováno v: The Journal of cell biology [J Cell Biol] 2020 Jul 06; Vol. 219 (7).

Reovirus σNS and μNS Proteins Remodel the Endoplasmic Reticulum to Build Replication Neo-Organelles.

Autor: Tenorio R; Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, Campus UAM, Madrid, Spain., Fernández de Castro I; Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, Campus UAM, Madrid, Spain., Knowlton JJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Zamora PF; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Lee CH; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Mainou BA; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Dermody TS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA terence.dermody@chp.edu crisco@cnb.csic.es.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Risco C; Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, Campus UAM, Madrid, Spain terence.dermody@chp.edu crisco@cnb.csic.es.

Publikováno v: MBio [mBio] 2018 Aug 07; Vol. 9 (4). Date of Electronic Publication: 2018 Aug 07.

The TRiC chaperonin controls reovirus replication through outer-capsid folding.

Autor: Knowlton JJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fernández de Castro I; National Center for Biotechnology, Spanish National Research Council, CNB-CSIC, Madrid, Spain., Ashbrook AW; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA., Gestaut DR; Department of Biology, Stanford University, Palo Alto, CA, USA., Zamora PF; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bauer JA; Department of Biochemistry, Institute of Chemical Biology, High-Throughput Screening Facility, Vanderbilt University School of Medicine, Nashville, TN, USA., Forrest JC; Department of Microbiology and Immunology, Center for Microbial Pathogenesis and Host Responses, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Frydman J; Department of Biology, Stanford University, Palo Alto, CA, USA., Risco C; National Center for Biotechnology, Spanish National Research Council, CNB-CSIC, Madrid, Spain., Dermody TS; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. terence.dermody@chp.edu.; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. terence.dermody@chp.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2018 Apr; Vol. 3 (4), pp. 481-493. Date of Electronic Publication: 2018 Mar 12.