Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide

Autor: Patricia Cámara-Sánchez, Zamira V. Díaz-Riascos, Natalia García-Aranda, Petra Gener, Joaquin Seras-Franzoso, Micaela Giani-Alonso, Miriam Royo, Esther Vázquez, Simó Schwartz, Ibane Abasolo

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 19, p 11760 (2022)

Cancer maintenance, metastatic dissemination and drug resistance are sustained by cancer stem cells (CSCs). Triple negative breast cancer (TNBC) is the breast cancer subtype with the highest number of CSCs and the poorest prognosis. Here, we aimed to

Externí odkaz: https://doaj.org/article/5c5fc6dac2a84aada7ff9d3beb2f795e

Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders

Autor: Joaquin Seras‐Franzoso, Zamira V. Díaz‐Riascos, José Luis Corchero, Patricia González, Natalia García‐Aranda, Mònica Mandaña, Roger Riera, Ana Boullosa, Sandra Mancilla, Alba Grayston, Marc Moltó‐Abad, Elena Garcia‐Fruitós, Rosa Mendoza, Guillem Pintos‐Morell, Lorenzo Albertazzi, Anna Rosell, Josefina Casas, Antonio Villaverde, Simó Schwartz Jr, Ibane Abasolo

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 5, Pp n/a-n/a (2021)

Abstract In the present study the use of extracellular vesicles (EVs) as vehicles for therapeutic enzymes in lysosomal storage disorders was explored. EVs were isolated from mammalian cells overexpressing alpha‐galactosidase A (GLA) or N‐sulfoglu

Externí odkaz: https://doaj.org/article/017c9b6b0e7544dbad5fbbce1391a4b6

Extracellular vesicles secreted by triple-negative breast cancer stem cells trigger premetastatic niche remodeling and metastatic growth in the lungs

Autor: Patricia González‐Callejo, Petra Gener, Zamira V. Díaz‐Riascos, Sefora Conti, Patricia Cámara‐Sánchez, Roger Riera, Sandra Mancilla, Miguel García‐Gabilondo, Vicente Peg, Diego Arango, Anna Rosell, Anna Labernadie, Xavier Trepat, Lorenzo Albertazzi, Simó Schwartz, Joaquin Seras‐Franzoso, Ibane Abasolo

Publikováno v: International Journal of Cancer, 152(10), 2153-2165. Wiley-Liss Inc.

Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the premetastatic niche (PMN) to support cancer cell engraftment and metastatic growth. However, complex cancer ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f4119a9b6196eb6238c76006d4aad7
https://doi.org/10.1002/ijc.34447

Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

Autor: Simó Schwartz, Fernanda Andrade, Zamira V. Díaz-Riascos, Patricia Cámara-Sánchez, Petra Gener, Diana Rafael, Ibane Abasolo, Joaquin Seras-Franzoso, Marwa M Abu-Serie

Publikováno v: Nanomedicine (London, England). 16(17)

Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic® F127 and its efficacy tested on the growth of four breast ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bbcd18a2272ce0d294d75db0588bd6
https://pubmed.ncbi.nlm.nih.gov/34160295

Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment

Autor: Santi Sala, Irina Portnaya, Patricia Cámara-Sánchez, Jeppe Lyngsø, José Luis Corchero, Natalia García-Aranda, Ibane Abasolo, Josep Merlo-Mas, Edgar Cristóbal-Lecina, Daniel Pulido, Simó Schwartz, Alba Córdoba, Jan Skov Pedersen, Dganit Danino, Judit Tomsen-Melero, Ramon González-Rioja, Solène Passemard, Nora Ventosa, Zamira V. Díaz-Riascos, Elisabet González-Mira, Miriam Royo, Jannik Nedergaard Pedersen, Jaume Veciana, Inbal Abutbul Ionita

Publikováno v: ACS Applied Materials & Interfaces
Tomsen-Melero, J, Passemard, S, García-Aranda, N, Días-Riascos, Z V, González-Rioja, R, Pedersen, J N, Lyngsø, J, Merlo-Mas, J, Cristóbal-Lecina, E, Corchero, J L, Pulido, D, Cámara-Sánchez, P, Portnaya, I, Ionita, I, Schwarz, Jr., S, Veciana, J, Sala, S, Royo, M, Córdoba, A, Danino, D, Pedersen, J S, González-Mira, E, Abasolo, I & Ventosa, N 2021, ' Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment ', ACS applied materials & interfaces, vol. 13, no. 7, pp. 7825-7838 . https://doi.org/10.1021/acsami.0c16871
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Fabry disease is a rare lysosomal storage disorder characterized by a deficiency of α-galactosidase A (GLA), a lysosomal hydrolase. The enzyme replacement therapy administering naked GLA shows several drawbacks including poor biodistribution, limite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091577b5b2efbd8952090b16a5c62ad3