ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.

Autor: Remsberg JR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Suciu RM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Zambetti NA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Hanigan TW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Firestone AJ; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Inguva A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Long A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Ngo N; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Lum KM; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Henry CL; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Richardson SK; Department of Chemistry, University of Connecticut, Storrs, CT, USA., Predovic M; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Huang B; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Dix MM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Howell AR; Department of Chemistry, University of Connecticut, Storrs, CT, USA., Niphakis MJ; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA. MIIP@lundbeck.com., Shannon K; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Kevin.Shannon@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. Kevin.Shannon@ucsf.edu., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2021 Aug; Vol. 17 (8), pp. 856-864. Date of Electronic Publication: 2021 Apr 29.

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.

Autor: Zambetti NA; Department of Pediatrics.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA., Firestone AJ; Department of Pediatrics.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA., Remsberg JR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Huang BJ; Department of Pediatrics.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA., Wong JC; Department of Pediatrics.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA., Long AM; Department of Pediatrics., Predovic M; Department of Pediatrics., Suciu RM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Inguva A; Department of Pediatrics., Kogan SC; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA., Haigis KM; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA; and.; Department of Medicine, Harvard University Medical School, Boston, MA., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA., Shannon K; Department of Pediatrics.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.

Publikováno v: Blood [Blood] 2020 May 14; Vol. 135 (20), pp. 1772-1782.

ABHD17C represses apoptosis and pyroptosis in hepatocellular carcinoma cells.

Autor: WANG, LINPEI^1,2, WANG, JIAWEI², SHI, CHUNFENG², WANG, WEI² Wangwei9909@fjmu.edu.cn, WU, JIAN¹ drwujian@zju.edu.cn

Publikováno v: Biocell. 2024, Vol. 48 Issue 9, p1299-1310. 12p.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

Autor: Zambetti NA; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Ping Z; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Chen S; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Kenswil KJG; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Mylona MA; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Sanders MA; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Hoogenboezem RM; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Bindels EMJ; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Adisty MN; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Van Strien PMH; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., van der Leije CS; Department of Internal Medicine, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Westers TM; Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam 1081HV, the Netherlands., Cremers EMP; Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam 1081HV, the Netherlands., Milanese C; Department of Molecular Genetics, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Mastroberardino PG; Department of Molecular Genetics, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., van Leeuwen JPTM; Department of Internal Medicine, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., van der Eerden BCJ; Department of Internal Medicine, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Touw IP; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., Kuijpers TW; Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Centre (AMC), University of Amsterdam (UvA), Amsterdam 1105AZ, the Netherlands., Kanaar R; Departments of Genetics and Radiation Oncology, Cancer Genomics Center, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands., van de Loosdrecht AA; Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam 1081HV, the Netherlands., Vogl T; Institute of Immunology, University of Münster, Münster 48149, Germany., Raaijmakers MHGP; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam 3015CN, the Netherlands. Electronic address: m.h.g.raaijmakers@erasmusmc.nl.

Publikováno v: Cell stem cell [Cell Stem Cell] 2016 Nov 03; Vol. 19 (5), pp. 613-627. Date of Electronic Publication: 2016 Sep 22.

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.

Autor: Zambetti NA; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Bindels EM; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Van Strien PM; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Valkhof MG; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands Current address: Laboratory for Cell Therapy, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands., Adisty MN; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Hoogenboezem RM; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Sanders MA; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Rommens JM; Program in Genetics & Genome Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Department of Molecular Genetics, University of Toronto, ON, Canada., Touw IP; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Raaijmakers MH; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands m.h.g.raaijmakers@erasmusmc.nl.

Publikováno v: Haematologica [Haematologica] 2015 Oct; Vol. 100 (10), pp. 1285-93. Date of Electronic Publication: 2015 Jul 16.