Generation of anti-virulence compounds against the type three secretion system of Escherichia coli O157:H7

Autor: Zambelloni, Riccardo

Escherichia coli is normally found in the intestinal microbiota of most mammals and is regarded as a commensal bacterium. However, several strains have evolved as pathogens through the acquisition of pathogenicity islands. E. coli O157:H7 is a commen

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705591

Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition

Autor: Zambelloni, Riccardo, Connolly, James P.R., Huerta Uribe, Alejandro, Burgess, Karl, Marquez, Rodolfo, Roe, Andrew J.

Publikováno v: Molecular Microbiology
Zambelloni, R, Connolly, J P R, Uribe, A H, Burgess, K, Marquez, R & Roe, A J 2017, ' Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition ', Molecular Microbiology, vol. 105, no. 4, pp. 606-619 . https://doi.org/10.1111/mmi.13719

Anti-virulence (AV) compounds are a promising alternative to traditional antibiotics for fighting bacterial infections. The Type Three Secretion System (T3SS) is a well-studied and attractive AV target, given that it is widespread in more than 25 spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1f7a0d218bfc57c704a7de3f6635ed52
http://europepmc.org/articles/PMC5575525

Crystal structures of WrbA, a spurious target of the salicylidene acylhydrazide inhibitors of type III secretion in Gram-negative pathogens, and verification of improved specificity of next-generation compounds.

Autor: Zambelloni R; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Glasgow, G12 8TA, UK.; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.; Sygnature Discovery Ltd, Biocity, Discovery Building, Nottingham, NG1 1GR, UK., Beckham KSH; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Glasgow, G12 8TA, UK.; EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany., Wu HJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Glasgow, G12 8TA, UK., Elofsson M; Umeå Centre for Microbial Research, Department of Chemistry, Umeå University, Umeå, Sweden., Marquez R; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.; School of Physical and Chemical Sciences, Te Kura Matū, University of Canterbury, Christchurch, New Zealand., Gabrielsen M; MVLS Structural Biology and Biophysical Characterisation Facility, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Roe AJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Glasgow, G12 8TA, UK.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2022 Jul; Vol. 168 (7).