Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Zalfa A. Abdel Malek"'
Autor:
Parth R. Upadhyay, Renny J. Starner, Viki B. Swope, Kazumasa Wakamatsu, Shosuke Ito, Zalfa A. Abdel-Malek
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1204 (2022)
Constitutive pigmentation determines the response to sun exposure and the risk for melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes, we compared the effects of constitutive pigmentation on their antioxidant re
Externí odkaz:
https://doaj.org/article/6b364469fc034ea895af20bbeb444237
Publikováno v:
Pigment Cell Melanoma Res
Human epidermal melanocytes play a central role in sensing the environment and protecting the skin from the drastic effects of solar ultraviolet radiation and other environmental toxins or inflammatory agents. Melanocytes survive in the epidermis for
Autor:
Zalfa A. Abdel-Malek, Viki Swope
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
The membrane bound melanocortin 1 receptor (MC1R), and the endothelin B receptor (ENDBR) are two G-protein coupled receptors that play important roles in constitutive regulation of melanocytes and their response to ultraviolet radiation (UVR), the ma
Externí odkaz:
https://doaj.org/article/3b271f2caf00423cb72e301e8bf8b495
Autor:
Zalfa A. Abdel-Malek, Tina Ho, Iltefat H. Hamzavi, Alan B. Fleischer, Parth Rajendrakumar Upadhyay, Christian S. Jordan
Publikováno v:
Pigment Cell & Melanoma Research. 33:778-787
Vitiligo is the most common acquired pigmentary disorder, which afflicts 0.5%-1% of the world population, and is characterized by depigmented skin patches resulting from melanocyte loss. Vitiligo has a complex etiology and varies in its manifestation
Autor:
Christopher M. Lloyd, Kelly A. Combs, Dorothy M. Supp, Viki B. Swope, Steven T. Boyce, Zalfa A. Abdel-Malek, Jennifer M. Hahn
Publikováno v:
Journal of Burn Care & Research. 41:751-760
Engineered skin substitutes (ESS) containing autologous fibroblasts and keratinocytes provide stable wound closure in patients with large, full-thickness burns, but are limited by hypopigmentation due to absence of added melanocytes. DNA damage cause
Autor:
Viki B. Swope, Zalfa A. Abdel-Malek
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2667 (2018)
Melanin, the pigment produced by specialized cells, melanocytes, is responsible for skin and hair color. Skin pigmentation is an important protective mechanism against the DNA damaging and mutagenic effects of solar ultraviolet radiation (UV). It is
Externí odkaz:
https://doaj.org/article/feb62eac321b45fe86a54c765c860957
Autor:
Taylor L Braunberger, Iltefat H. Hamzavi, Indermeet Kohli, Henry W. Lim, Zalfa A. Abdel-Malek, Amanda F Nahhas
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 35:420-428
Oxidative stress is an integral element that influences a variety of biochemical reactions throughout the body and is known to play a notable role in melanogenesis. Exogenous triggers of oxidative stress, such as ultraviolet radiation (UVR) and visib
Autor:
Darrel L. Ellis, Maria L. Wei, Jennifer G. Powers, Svetomir N. Markovic, Jerry D. Brewer, Fabian V. Filipp, John A. Thompson, Mark R. Albertini, Joanne M. Jeter, Suephy C. Chen, John M. Kirkwood, Susan M. Swetter, Jennifer L. Hay, Aaron R. Mangold, Debjani Sahni, Emily Y. Chu, Clara Curiel-Lewandrowski, Jack L. Arbiser, Mohammed Kashani-Sabet, Tawnya L. Bowles, Kelly C. Nelson, Douglas Grossman, Pamela B. Cassidy, Jeffrey E. Gershenwald, Michael E. Ming, Zalfa A. Abdel-Malek, David E. Fisher, Pauline Funchain, Robert P. Dellavalle, June K. Robinson, Ashfaq A. Marghoob, Kari Kendra, Vernon K. Sondak, Sherry L. Pagoto, John T. Vetto, Martin A. Weinstock, Kim Margolin, Sancy A. Leachman, Neil F. Box, Jonathan S. Zager, Larisa J. Geskin, Aleksandar Sekulic
Publikováno v:
Cancer. 125:18-44
Recent progress in the treatment of advanced melanoma has led to unprecedented improvements in overall survival and, as these new melanoma treatments have been developed and deployed in the clinic, much has been learned about the natural history of t
Publikováno v:
Pigment Cell & Melanoma Research. 34:705-706
Autor:
Zalfa A. Abdel-Malek, Carrie Haskell-Luevano, Renny J. Starner, Leonid Koikov, Parth Rajendrakumar Upadhyay, Katie T. Freeman, James J. Knittel, Yuki Hashimoto, Viki B. Swope
Publikováno v:
J Invest Dermatol
Activation of the human melanocortin 1 receptor (hMC1R) expressed on melanocytes by α-melanocortin plays a central role in regulating human pigmentation and reducing the genotoxicity of UV by activating DNA repair and antioxidant defenses. For the d