Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development

Autor: Zaksauskaite, R., Thomas, R.C., van Eeden, F., El-Khamisy, S.F.

Deficiency in the DNA end-processing enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1), causes progressive neurodegeneration in humans. Here, we generated a tdp1 knockout zebrafish and confirmed the lack of TDP1 activity. In adulthood, homozygotes exhib

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Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development.

Autor: Zaksauskaite R; Healthy Lifespan Institute, Sheffield Institute for Neuroscience, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK., Thomas RC; Healthy Lifespan Institute, Sheffield Institute for Neuroscience, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.; Bateson Centre, Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, UK., van Eeden F; Healthy Lifespan Institute, Sheffield Institute for Neuroscience, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. s.el-khamisy@sheffield.ac.uk f.j.vaneeden@sheffield.ac.uk.; Bateson Centre, Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, UK., El-Khamisy SF; Healthy Lifespan Institute, Sheffield Institute for Neuroscience, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. s.el-khamisy@sheffield.ac.uk f.j.vaneeden@sheffield.ac.uk.; The Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.

Publikováno v: Science advances [Sci Adv] 2021 Jan 29; Vol. 7 (5). Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).