Deciphering the biology of KIR2DL3+ T lymphocytes that are associated to relapse in haploidentical HSCT

Autor: Gaëlle David, Catherine Willem, Nolwenn Legrand, Zakia Djaoud, Pierre Mérieau, Alexandre Walencik, Thierry Guillaume, Katia Gagne, Patrice Chevallier, Christelle Retière

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract KIR are mainly expressed on NK cells and to a lesser extent on T lymphocytes. Although the KIR NK cell repertoire was well explored in haploidentical Hematopoietic Stem Cell Transplantation (HSCT), KIR T cell compartment remains to be invest

Externí odkaz: https://doaj.org/article/6d647b4ddb4e4b30bc075d7c4404c291

The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

Autor: Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, Zakia Djaoud, Lisbeth A. Guethlein, Jeroen H. Blokhuis, Jason L. Pugh, Ana Goyos, Amir Horowitz, Rico Buchli, Ken W. Jackson, Wilfred Bardet, David A. Bushnell, Philip J. Robinson, Juan L. Mendoza, Michael E. Birnbaum, Morten Nielsen, K. Christopher Garcia, William H. Hildebrand, Peter Parham

Publikováno v: Cell Reports, Vol 19, Iss 7, Pp 1394-1405 (2017)

HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-co

Externí odkaz: https://doaj.org/article/80996e0dab9f4ff09d46ee3a014674f3

Supplementary Figure from Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self

Autor: Zakia Djaoud, Peter Parham, Lisbeth A. Guethlein, Daniel Olive, Bernhard B. Singer, Niassan Beyzaie, Alexander T.H. Cocker, Jason Pugh, Katherine Walwyn-Brown

Supplementary Figure from Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de2334d87c73d5a259d55e5d8957ad3
https://doi.org/10.1158/2326-6066.22544057

Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self

Autor: Katherine Walwyn-Brown, Jason Pugh, Alexander T.H. Cocker, Niassan Beyzaie, Bernhard B. Singer, Daniel Olive, Lisbeth A. Guethlein, Peter Parham, Zakia Djaoud

Publikováno v: Cancer Immunol Res
CANCER IMMUNOLOGY RESEARCH
CANCER IMMUNOLOGY RESEARCH, 2022, 10 (5), pp.558-570. ⟨10.1158/2326-6066.CIR-21-0696⟩

γδ T cells stimulated by phosphoantigens (pAg) are potent effectors that secrete Th1 cytokines and kill tumor cells. Consequently, they are considered candidates for use in cancer immunotherapy. However, they have proven only moderately effective i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08620bfd12fcec8bd3c61bdafe1511ba
https://doi.org/10.1158/2326-6066.cir-21-0696

Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells

Autor: Amir Horowitz, Zakia Djaoud, Paul Norman, Tarik Azzi, Peter Parham, David Nadal, Christian Münz, Neda Nemat-Gorgani, Daniel Olive, Lisbeth A. Guethlein

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2017, 214 (6), pp.1827-1841. ⟨10.1084/jem.20161017⟩
Journal of Experimental Medicine, Rockefeller University Press, 2017, 214 (6), pp.1827-1841. ⟨10.1084/jem.20161017⟩
The Journal of Experimental Medicine

Djaoud et al. show that Epstein–Barr virus infection triggers two types of human innate immune response, one mediated by the combination of NK cells and γδ T cells and the other committed to a strong NK cell response with little involvement of γ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8225c8cbc0e844a5b6202da0a88cdb1d
https://doi.org/10.1084/jem.20161017