Zobrazeno 1 - 10 of 569 pro vyhledávání: '"Zakharov Si"'
1
Report
Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current.
Autor: Katchman AN; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Zakharov SI; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Bohnen MS; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Sanchez Jimenez A; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Kushner JS; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Yang L; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Chen BX; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Nasari A; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.; CUNY School of Medicine, New York, NY (A.N.)., Liu G; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Rabbani DE; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Han J; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY (J.H., C.-S.L.)., Leu CS; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY (J.H., C.-S.L.)., Pitt GS; Cardiovascular Research Institute and Department of Medicine, Weill Cornell Medical College, New York, NY (G.S.P.)., Marx SO; Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.; Department of Pharmacology and Molecular Signaling (S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.
Publikováno v: Circulation [Circulation] 2024 May 14; Vol. 149 (20), pp. 1617-1620. Date of Electronic Publication: 2024 May 13.
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2
Akademický článek
A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.
Autor: Papa A; Division of Cardiology, Department of Medicine, and.; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Del Rivero Morfin PJ; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Chen BX; Division of Cardiology, Department of Medicine, and., Yang L; Division of Cardiology, Department of Medicine, and., Katchman AN; Division of Cardiology, Department of Medicine, and., Zakharov SI; Division of Cardiology, Department of Medicine, and., Liu G; Division of Cardiology, Department of Medicine, and., Bohnen MS; Division of Cardiology, Department of Medicine, and., Zheng V; Division of Cardiology, Department of Medicine, and., Katz M; Faculty of Medicine and., Subramaniam S; Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Hirsch JA; Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Weiss S; Faculty of Medicine and., Dascal N; Faculty of Medicine and., Karlin A; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Pitt GS; Cardiovascular Research Institute and Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Colecraft HM; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Pharmacology and Molecular Signaling, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Marx SO; Division of Cardiology, Department of Medicine, and.; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Pharmacology and Molecular Signaling, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Jan 16; Vol. 134 (5). Date of Electronic Publication: 2024 Jan 16.
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3
Akademický článek
Rad regulation of Ca V 1.2 channels controls cardiac fight-or-flight response.
Autor: Papa A; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Zakharov SI; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Katchman AN; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Kushner JS; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Chen BX; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Yang L; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Liu G; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Jimenez AS; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Eisert RJ; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Bradshaw GA; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Dun W; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Ali SR; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Rodriques A; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Zhou K; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Topkara V; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Yang M; Institute for Genomic Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Morrow JP; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Tsai EJ; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Karlin A; Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA., Wan E; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Kalocsay M; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Present address: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pitt GS; Cardiovascular Research Institute and Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Colecraft HM; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pharmacology and Molecular Signaling, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Marx SO; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pharmacology and Molecular Signaling, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Nov; Vol. 1 (11), pp. 1022-1038. Date of Electronic Publication: 2022 Nov 14.
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4
Akademický článek
Adrenergic Ca V 1.2 Activation via Rad Phosphorylation Converges at α 1C I-II Loop.
Autor: Papa A; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.; Department of Physiology and Cellular Biophysics (A.P., J.D., P.J.d.R.M., H.M.C., O.C., M.B.-J.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Kushner J; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Hennessey JA; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Katchman AN; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Zakharov SI; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Chen BX; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Yang L; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Lu R; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Leong S; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Diaz J; Department of Physiology and Cellular Biophysics (A.P., J.D., P.J.d.R.M., H.M.C., O.C., M.B.-J.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Liu G; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Roybal D; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.; Department of Pharmacology and Molecular Signaling (D.R., H.M.C., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Liao X; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Del Rivero Morfin PJ; Department of Physiology and Cellular Biophysics (A.P., J.D., P.J.d.R.M., H.M.C., O.C., M.B.-J.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Colecraft HM; Department of Physiology and Cellular Biophysics (A.P., J.D., P.J.d.R.M., H.M.C., O.C., M.B.-J.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.; Department of Pharmacology and Molecular Signaling (D.R., H.M.C., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Pitt GS; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York (G.S.P.)., Clarke O; Department of Physiology and Cellular Biophysics (A.P., J.D., P.J.d.R.M., H.M.C., O.C., M.B.-J.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Topkara V; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Ben-Johny M; Department of Physiology and Cellular Biophysics (A.P., J.D., P.J.d.R.M., H.M.C., O.C., M.B.-J.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY., Marx SO; Division of Cardiology, Department of Medicine (A.P., J.K., J.A.H., A.N.K., S.I.Z., B.-x.C., L.Y., R.L., S.L., G.L., D.R., X.L., V.T., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.; Department of Pharmacology and Molecular Signaling (D.R., H.M.C., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY.
Publikováno v: Circulation research [Circ Res] 2021 Jan 08; Vol. 128 (1), pp. 76-88. Date of Electronic Publication: 2020 Oct 22.
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5
Akademický článek
Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
Autor: Abrams J; Division of Cardiology, Department of Medicine., Roybal D; Department of Pharmacology, and., Chakouri N; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Katchman AN; Division of Cardiology, Department of Medicine., Weinberg R; Division of Cardiology, Department of Medicine., Yang L; Division of Cardiology, Department of Medicine., Chen BX; Division of Cardiology, Department of Medicine., Zakharov SI; Division of Cardiology, Department of Medicine., Hennessey JA; Division of Cardiology, Department of Medicine., Avula UMR; Division of Cardiology, Department of Medicine., Diaz J; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Wang C; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Wan EY; Division of Cardiology, Department of Medicine., Pitt GS; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Marx SO; Division of Cardiology, Department of Medicine.; Department of Pharmacology, and.
Publikováno v: JCI insight [JCI Insight] 2020 Oct 02; Vol. 5 (19). Date of Electronic Publication: 2020 Oct 02.
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6
Akademický článek
Mechanism of adrenergic Ca V 1.2 stimulation revealed by proximity proteomics.
Autor: Liu G; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Papa A; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Katchman AN; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Zakharov SI; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Roybal D; Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Hennessey JA; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Kushner J; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Yang L; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Chen BX; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Kushnir A; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Dangas K; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Pitt GS; Cardiovascular Research Institute, Weill Cornell Medical College, New York, NY, USA., Colecraft HM; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Kalocsay M; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA. Marian_Kalocsay@hms.harvard.edu., Marx SO; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA. sm460@cumc.columbia.edu.; Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA. sm460@cumc.columbia.edu.
Publikováno v: Nature [Nature] 2020 Jan; Vol. 577 (7792), pp. 695-700. Date of Electronic Publication: 2020 Jan 22.
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7
Akademický článek
Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery.
Autor: Koziol-White, Cynthia1 (AUTHOR) cjk167@rbhs.rutgers.edu, Gebski, Eric1 (AUTHOR), Cao, Gaoyaun1 (AUTHOR), Panettieri Jr., Reynold A.1 (AUTHOR)
Publikováno v: Respiratory Research. 6/1/2024, Vol. 25, p1-21. 21p.
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8
Akademický článek
Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.
Autor: Yang L; Division of Cardiology, Department of Medicine, Columbia University., Katchman A; Division of Cardiology, Department of Medicine, Columbia University., Kushner J; Division of Cardiology, Department of Medicine, Columbia University., Kushnir A; Division of Cardiology, Department of Medicine, Columbia University., Zakharov SI; Division of Cardiology, Department of Medicine, Columbia University., Chen BX; Division of Cardiology, Department of Medicine, Columbia University., Shuja Z; Department of Physiology and Cellular Biophysics, and., Subramanyam P; Department of Physiology and Cellular Biophysics, and., Liu G; Division of Cardiology, Department of Medicine, Columbia University., Papa A; Department of Physiology and Cellular Biophysics, and., Roybal D; Department of Pharmacology, Vagelos College of Physicians and Surgeons, New York, New York, USA., Pitt GS; Cardiovascular Research Institute, Weill Cornell Medical College, New York, New York, USA., Colecraft HM; Department of Physiology and Cellular Biophysics, and.; Department of Pharmacology, Vagelos College of Physicians and Surgeons, New York, New York, USA., Marx SO; Division of Cardiology, Department of Medicine, Columbia University.; Department of Pharmacology, Vagelos College of Physicians and Surgeons, New York, New York, USA.
Publikováno v: The Journal of clinical investigation [J Clin Invest] 2019 Feb 01; Vol. 129 (2), pp. 647-658. Date of Electronic Publication: 2019 Jan 07.
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Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits
Autor: Yang, L, Liu, Gx, Zakharov, Si, Bellinger, Am, Mongillo, Marco, Marx, So
Publikováno v: Circulation research. 101(5)
Voltage-dependent Ca(2+) channel function (Ca(v)1.2, L-type Ca(2+) channel) is required for cardiac excitation-contraction (E-C) coupling. Ca(v)1.2 plays a key role in modulating cardiac function in response to classic signaling pathways, such as the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4bafa9be12e52b11069521211d0d6bce
https://pubmed.ncbi.nlm.nih.gov/17626895
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