CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8 ⁺ T cells in diabetic autoimmunity.

Autor: Srivastava N; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Hu H; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Peterson OJ; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Vomund AN; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Stremska M; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA., Zaman M; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Giri S; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Li T; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA., Lichti CF; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Zakharov PN; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA., Zhang B; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA., Abumrad NA; Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Chen YG; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Ravichandran KS; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; VIB/UGent Inflammation Research Centre and Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Unanue ER; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Wan X; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: wanx@wustl.edu.

Publikováno v: Immunity [Immunity] 2024 Jul 09; Vol. 57 (7), pp. 1629-1647.e8. Date of Electronic Publication: 2024 May 15.

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes.

Autor: Zakharov PN; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Hu H; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Wan X; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Unanue ER; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2020 Jun 01; Vol. 217 (6).

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.

Autor: Ferris ST; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Zakharov PN; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Wan X; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Calderon B; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Unanue ER; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO unanue@wustl.edu., Carrero JA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO jacarrer@wustl.edu.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2017 Aug 07; Vol. 214 (8), pp. 2369-2385. Date of Electronic Publication: 2017 Jun 19.