Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zakey Yusuf Buuh"'
Autor:
Benjamin L. Prather, Shuyue Ji, Yue Zhao, Femil Joseph Shajan, Mi Zhao, Zakey Yusuf Buuh, Robert Maloney, Rui Zhang, Carson Cohen, Rongsheng E. Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 204-212 (2023)
Chemicals possessing reactive electrophiles can denature innate proteins leading to undesired toxicity, and the overdose-induced liver injury by drugs containing electrophiles has been one of the major causes of non-approval and withdraw by the US Fo
Externí odkaz:
https://doaj.org/article/f915452817ff4e0fa36eefacb2c222b4
Autor:
Md Shafiqul Islam, Samuel L. Junod, Si Zhang, Zakey Yusuf Buuh, Yifu Guan, Mi Zhao, Kishan H. Kaneria, Parmila Kafley, Carson Cohen, Robert Maloney, Zhigang Lyu, Vincent A. Voelz, Weidong Yang, Rongsheng E. Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Strategies capable of stapling unprotected peptides in a straightforward, chemoselective, and clean manner, as well as promoting cellular uptake are of great interest. Here the authors report a peptide macrocyclization and stapling strategy which sat
Externí odkaz:
https://doaj.org/article/f87430b3787e42cbbe8ea65567d72d8b
Autor:
Zakey Yusuf Buuh, Nicole Gorman, Hsin-Yao Tang, Zhigang Lyu, Aaron R. Goldman, Yue Zhao, Rongsheng E. Wang, Shafiqul Islam
Publikováno v:
J Am Chem Soc
We have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine–thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chemical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d9e8b4916effd0b37dc679ede3c0f7
https://doi.org/10.1021/jacs.0c05605
https://doi.org/10.1021/jacs.0c05605
Autor:
Shafiqul Islam, Nicole Gorman, Yue Zhao, Hsin-Yao Tang, Zakey Yusuf Buuh, Zhigang Lyu, Rongsheng E. Wang, Aaron R. Goldman
We have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine-thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chemical rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb4087502471f96dce47e86ac307286
https://doi.org/10.1101/2020.09.09.290221
https://doi.org/10.1101/2020.09.09.290221
Autor:
Zakey Yusuf Buuh, Vincent A. Voelz, Y. Guan, Weidong Yang, K. H. Kaneria, Zhigang Lyu, Samuel L. Junod, Rongsheng E. Wang, M. S. Islam, Si Zhang
Stapled peptides serve as a powerful tool for probing protein-protein interactions, but its application has been largely impeded by the limited cellular uptake. Here we report the discovery of a facile peptide macrocyclization and stapling strategy b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823c37be17e2f9c8f4046e9dc964f0de
https://doi.org/10.1101/2020.09.09.290379
https://doi.org/10.1101/2020.09.09.290379
Publikováno v:
Methods Enzymol
This work details the use of amber suppression-mediated genetic incorporation of unnatural amino acids (UAAs), specifically p-azido-l-phenylalanine (pAzF) and p-acetyl-l-phenylalanine (pAcF), to develop site-specifically labeled antibody Fab fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2173c0af7c8983e7de13f1f443e93574
https://pubmed.ncbi.nlm.nih.gov/32416919
https://pubmed.ncbi.nlm.nih.gov/32416919
Autor:
Dawei Jiang, Jeffrey C. McGuth, Lei Kang, Haley L. Wissler, Weibo Cai, Zhigang Lyu, Juanjuan Du, Zakey Yusuf Buuh, Rongsheng E. Wang
Publikováno v:
ACS Chemical Biology. 13:958-964
Genetic incorporation of unnatural amino acids (UAAs) provides a unique approach to the synthesis of site-specific antibody conjugates that are homogeneous and better defined constructs than random conjugates. Yet, the yield varies for every antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6457e5f0d174c3fe15a2101b2820aa
https://doi.org/10.1021/acschembio.8b00107
https://doi.org/10.1021/acschembio.8b00107
Publikováno v:
Journal of Medicinal Chemistry. 61:3239-3252
Post-translational modifications (PTMs) allot versatility to the biological functions of highly conserved proteins. Recently, modifications to non-histone proteins such as methylation, acetylation, phosphorylation, glycosylation, ubiquitination, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd3e04683b5341a549f5298ab50d3806
https://doi.org/10.1021/acs.jmedchem.6b01817
https://doi.org/10.1021/acs.jmedchem.6b01817
Autor:
Emily B. Ehlerding, Haley L. Wissler, Zakey Yusuf Buuh, Si Zhang, Rongsheng E. Wang, Jeffrey C. McGuth, Yue Zhao, Weibo Cai, Anisa R. Eshraghi, Jonathan W. Engle, Zhigang Lyu, Yifu Guan, Vincent A. Voelz, Sarah J Bartlett
Publikováno v:
Mol Pharm
The rapid ascension of immune checkpoint blockade treatments has placed an emphasis on the need for viable, robust, and noninvasive imaging methods for immune checkpoint proteins, which could be of diagnostic value. Immunoconjugate-based positron emi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44345f7100595f684d7cde8629e0194b
https://pubmed.ncbi.nlm.nih.gov/30875232
https://pubmed.ncbi.nlm.nih.gov/30875232
Publikováno v:
Journal of medicinal chemistry. 61(8)
Post-translational modifications (PTMs) allot versatility to the biological functions of highly conserved proteins. Recently, modifications to non-histone proteins such as methylation, acetylation, phosphorylation, glycosylation, ubiquitination, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e9d8e49235c4c00613e1f990ba614f0
https://pubmed.ncbi.nlm.nih.gov/28505447
https://pubmed.ncbi.nlm.nih.gov/28505447