Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zakaria S. Khondker"'
Autor:
Mark M. Awad, Ramaswamy Govindan, Kristen N. Balogh, David R. Spigel, Edward B. Garon, Meghan E. Bushway, Asaf Poran, Joong Hyuk Sheen, Victoria Kohler, Ekaterina Esaulova, John Srouji, Suchitra Ramesh, Rohit Vyasamneni, Binisha Karki, Tracey E. Sciuto, Himanshu Sethi, Jesse Z. Dong, Melissa A. Moles, Kelledy Manson, Michael S. Rooney, Zakaria S. Khondker, Mark DeMario, Richard B. Gaynor, Lakshmi Srinivasan
Publikováno v:
Cancer cell. 40(9)
Neoantigens arising from mutations in tumor DNA provide targets for immune-based therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a personalized neoantigen-vaccine NEO-PV-01 in combination with pemetrexed, carbo
Autor:
Meghan E. Bushway, Melissa A. Moles, Amy Wanamaker, Zakaria S. Khondker, Mark DeMario, David R. Spigel, Jennifer Tepper, Mark Awad, Ramaswamy Govindan, Saiama N. Waqar, Kristen N. Balogh, Asaf Poran, Richard B. Gaynor, Edward B. Garon, Jesse Z. Dong, Aaron Lisberg, Lakshmi Srinivasan, April Lamb, John Srouji
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Neoantigens arising from mutations in cancer cell DNA are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides (14–35 amino acids) based on a patient‘s HLA profile a
Autor:
Meghan E. Bushway, Kristen N. Balogh, Lakshmi Srinivasan, Zakaria S. Khondker, Patrick A. Ott, Rana H. Besada, Richard B. Gaynor, Julian Scherer, Jasmina Prabhakara, Siwen Hu-Lieskovan, Michael S. Rooney, Reid G. Williams, Amy Wanamaker, Asaf Poran
Publikováno v:
Cell Reports Medicine
Summary T cells use highly diverse receptors (TCRs) to identify tumor cells presenting neoantigens arising from genetic mutations and establish anti-tumor activity. Immunotherapy harnessing neoantigen-specific T cells to target tumors has emerged as
Autor:
Lakshmi Srinivasan, Yvonne Ware, Kelledy Manson, Asaf Poran, Benjamin Trapp, Joel Greshock, Mark M. Awad, Dominik Barthelme, Dewi Harjanto, Victoria Kohler, Ying S. Ting, Richard B. Gaynor, Yuting Huang, Matthew D. Hellmann, Samantha J. Turnbull, Siwen Hu-Lieskovan, Ed Fritsch, Meghan E. Bushway, Jessica J. Lin, Lisa D. Cleary, Bartosz Chmielowski, Zhengping Huang, Michael S. Rooney, Terence W. Friedlander, Rana H. Besada, Patrick A. Ott, Zakaria S. Khondker, Mark DeMario, Kristen N. Balogh, Aung Naing, Melissa A. Moles, Riley R. Curran, Kim Margolin, Nina Bhardwaj, Tracey E. Sciuto, Jesse Z. Dong, Ramaswamy Govindan, Julian Scherer, Amy Wanamaker
Publikováno v:
Cell. 183(2)
Summary Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a personalized neoantigen-based vaccine, NEO-PV-01, in combina
Publikováno v:
American Journal of Orthodontics and Dentofacial Orthopedics. 137:316-323
Introduction Pain is a major concern of patients before orthodontic treatment. Currently, the most frequently recommended treatments for pain after archwire placement or appliance adjustment are over-the-counter (OTC) analgesics. Although the overuse
Publikováno v:
Cell Cycle. 8:3133-3148
We have recently shown that replication forks pause near origins in normal human fibroblasts (NHF1-hTERT) but not glioblastoma T98G cells. This observation led us to question whether other differences in the replication program may exist between thes
We propose a Bayesian generalized low-rank regression model (GLRR) for the analysis of both high-dimensional responses and covariates. This development is motivated by performing searches for associations between genetic variants and brain imaging ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fec1298db47554510c09a76b515e9e
Autor:
David W Olilla, Zakaria S. Khondker, Pei Fen Kuan, Kathleen Conway, Pamela A. Groben, Nancy E. Thomas, Marianne Berwick, Sharon N. Edmiston, Haitao Chu, Honglin Hao, Xin Zhou, Craig C. Carson
DNA methylation, an epigenetic alteration typically occurring early in cancer development, could aid in the molecular diagnosis of melanoma. We determined technical feasibility for high-throughput DNA-methylation array-based profiling using formalin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0580d5bc86a793db0717a5dbdc7da4e8
Publikováno v:
Scopus-Elsevier
Experts@Minnesota
Experts@Minnesota
Estimation of sparse covariance matrices and their inverse subject to positive definiteness constraints has drawn a lot of attention in recent years. The abundance of high-dimensional data, where the sample size (n) is less than the dimension (d), re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f7b92df94aa85956fafb944124f445
http://www.scopus.com/inward/record.url?eid=2-s2.0-84880141876&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84880141876&partnerID=MN8TOARS