Improving the Immunogenicity of the Mycobacterium bovis BCG Vaccine by Non-Genetic Bacterial Surface Decoration Using the Avidin-Biotin System.

Autor: Ting-Yu Angela Liao, Alice Lau, Sunil Joseph, Vesa Hytönen, Zakaria Hmama

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145833 (2015)

Current strategies to improve the current BCG vaccine attempt to over-express genes encoding specific M. tuberculosis (Mtb) antigens and/or regulators of antigen presentation function, which indeed have the potential to reshape BCG in many ways. Howe

Externí odkaz: https://doaj.org/article/8fec5acc3dbb4d168d36c44f1c388087

Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages.

Autor: Jim Sun, Xuetao Wang, Alice Lau, Ting-Yu Angela Liao, Cecilia Bucci, Zakaria Hmama

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8769 (2010)

Microorganisms capable of surviving within macrophages are rare, but represent very successful pathogens. One of them is Mycobacterium tuberculosis (Mtb) whose resistance to early mechanisms of macrophage killing and failure of its phagosomes to fuse

Externí odkaz: https://doaj.org/article/46e867c17ab246df8f2d571e96365bdd

Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System

Autor: Zakaria Hmama, Vesa P. Hytönen, Ting-Yu Angela Liao, Alice Lau, Joseph Sunil

Publikováno v: Journal of Visualized Experiments.

Tuberculosis (TB) is a serious infectious disease and the only available vaccine M. bovis bacillus Calmette-Guerin (BCG) is safe and effective for protection against children's severe TB meningitis and some forms of disseminated TB, but fails to prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd9097eca85269060322317db61a9d7
https://doi.org/10.3791/56421

Mycobacterium bovisBCG disrupts the interaction of Rab7 with RILP contributing to inhibition of phagosome maturation

Autor: Hafid Soualhine, Jim Sun, Cecilia Bucci, Thomas Hong, Zakaria Hmama, Ala-Eddine Deghmane, Anna Solodkin

Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2007, 82 (6), pp.1437-1445. ⟨10.1189/jlb.0507289⟩

Phagosomes containing M. tuberculosis and M. bovis BCG interact normally with early endosomes but fail to fuse with late endosomes and lysosomes. Whereas many early events of myco- bacterial phagosomes have been elucidated, the exact mechanism of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f797b46bdf58259f4fc26d41293c2f74
https://doi.org/10.1189/jlb.0507289

Mycobacterium bovis BCG Attenuates Surface Expression of Mature Class II Molecules through IL-10-Dependent Inhibition of Cathepsin S

Autor: Amina Talal, Ala-Eddine Deghmane, Zakaria Hmama, Yossef Av-Gay, Dmitri V. Pechkovsky, Khalid Sendide

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2005, 175 (8), pp.5324-5332. ⟨10.4049/jimmunol.175.8.5324⟩

We have previously shown that macrophage infection with Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) partially inhibits MHC class II surface expression in response to IFN-γ. The present study examined the nature of class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6a9640c9001a1bf344fca07df9cd98
https://doi.org/10.4049/jimmunol.175.8.5324