Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zakaria, Orfi"'
Autor:
Talita C. Conte, Gilberto Duran-Bishop, Zakaria Orfi, Inès Mokhtari, Alyson Deprez, Isabelle Côté, Thomas Molina, Tae-Yeon Kim, Lydia Tellier, Marie-Pier Roussel, Damien Maggiorani, Basma Benabdallah, Severine Leclerc, Lara Feulner, Ornella Pellerito, Jean Mathieu, Gregor Andelfinger, Cynthia Gagnon, Christian Beauséjour, Serge McGraw, Elise Duchesne, Nicolas A. Dumont
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients’ samples th
Externí odkaz:
https://doaj.org/article/72d4142afc3647a1818a01b7490a64b2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Muscle wasting in Duchenne Muscular Dystrophy is caused by myofiber fragility and poor regeneration that lead to chronic inflammation and muscle replacement by fibrofatty tissue. Our recent findings demonstrated that Resolvin-D2, a bioa
Externí odkaz:
https://doaj.org/article/8f034e07d71a4520a1d7c5f0f6a8741a
Autor:
Suleen Raad, Anu David, Melanie Sagniez, Bastien Paré, Zakaria Orfi, Nicolas A. Dumont, Martin A. Smith, Christophe Faure
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/ade1e6c981e445ef838b06a17f766496
Autor:
Junio Dort, Zakaria Orfi, Paul Fabre, Thomas Molina, Talita C. Conte, Karine Greffard, Ornella Pellerito, Jean-François Bilodeau, Nicolas A. Dumont
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids delay muscle wasting in Duchenne Muscular Dystrophy by reducing inflammation; but also have harmful side effects. Here, the authors show that Resolvin-D2 is more effective than glucocorticoids in mitigating muscular dystrophy in mouse
Externí odkaz:
https://doaj.org/article/b677507e81964e6ba72b1bd475989757
Publikováno v:
Bioscience Reports. 43
Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the MuSC niche, such as immune cells, play key roles to coordinate MuSC function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1face94fa03c7c201ceeb415c8a682b
https://doi.org/10.1042/bsr20220284
https://doi.org/10.1042/bsr20220284
Autor:
Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier, Joël Boutin, Junio Dort, Zakaria Orfi, Joris Michaud, Hugo Giguère, Alexandre Desroches, Kien Trân, François Vézina, Sonia Bedard, Catherine Raynaud, Frederic Balg, Philippe Sarret, Michelle S. Scott, Jerome N. Feige, Jean-Bernard Denault, Nicolas A. Dumont, Eric Marsault, Mannix Auger-Messier, C. Florian Bentzinger
Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here we describe that defects in the endothelial cell (EC) compartment of the perivascular stem cell niche in thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ef9e1393dd6bc0f84458d9e32277c0
https://doi.org/10.1101/2022.09.09.507274
https://doi.org/10.1101/2022.09.09.507274
Autor:
Talita C. Conte, Gilberto Duran-Bishop, Zakaria Orfi, Inès Mokhtari, Alyson Deprez, Marie-Pier Roussel, Isabelle Côté, Ornella Pellerito, Damien Maggiorani, Basma Benabdallah, Severine Leclerc, Lara Feulner, Jean Mathieu, Cynthia Gagnon, Gregor Andelfinger, Christian Beauséjour, Serge McGraw, Elise Duchesne, Nicolas A. Dumont
Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair, are also affected in this disease. However, the molecular mechanisms leading to this defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad73f6e36074aa0da3fb507bf7388fd
https://doi.org/10.1101/2022.06.22.497227
https://doi.org/10.1101/2022.06.22.497227
Autor:
Suleen Raad, Anu David, Melanie Sagniez, Zakaria Orfi, Nicolas A. Dumont, Martin Smith, Christophe Faure
SummaryA series of well-regulated cellular and molecular events result in the compartmentalization of the anterior foregut into the esophagus and trachea. Disruption of the compartmentalization process leads to esophageal atresia/tracheoesophageal fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c757792221175e1eadae100a814a63
https://doi.org/10.1101/2022.02.14.480418
https://doi.org/10.1101/2022.02.14.480418
Publikováno v:
Current Protocols. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0bdbdded649e07e55d539164fe288b
https://doi.org/10.1002/cpz1.356
https://doi.org/10.1002/cpz1.356
Autor:
Ying He, Alyson Deprez, Daniela Ravizzoni Dartora, Nicolas A. Dumont, Alexandra Radu, Zakaria Orfi, Anne Monique Nuyt, Junio Dort
Publikováno v:
Clinical Science.
Individuals born preterm show reduced exercise capacity and increased risk for pulmonary and cardiovascular diseases, but the impact of preterm birth on skeletal muscle, an inherently critical part of cardiorespiratory fitness, remains unknown. We ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21ba822e11ca20a1b4eeaf06257a87e
https://doi.org/10.1042/cs20210894
https://doi.org/10.1042/cs20210894