Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zak Doric"'
Autor:
Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral Oza, Ashkan Javaherian, Ken Nakamura, David Kokel, Steven Finkbeiner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cell death is a critical process in health and disease, yet available markers record later stages of cell death once a cell has already begun to decompose. Here the authors show the use of a genetically encoded calcium indicator that demarcates an ir
Externí odkaz:
https://doaj.org/article/2c47160676034ab2bc322fd5c88405c2
Autor:
Zak Doric, Ken Nakamura
Publikováno v:
Nature. 599:558-560
Mice in which organelles called mitochondria are disrupted in vulnerable neuronal cells provide a new model of Parkinson’s disease. The pattern of neurodegeneration challenges long-held ideas about the disease’s motor symptoms. Genetically engine
Autor:
Zak Doric, Ken Nakamura, Mai K. Nguyen, Giovanni Manfredi, Kevin McAvoy, Iris Lo, Huihui Li, Szu-Chi Liao
Publikováno v:
Human molecular genetics, vol 31, iss 9
Hum Mol Genet
Hum Mol Genet
Mutations in the mitochondrial protein CHCHD2 cause autosomal-dominant PD characterized by the preferential loss of substantia nigra dopamine (DA) neurons. Therefore, understanding the function of CHCHD2 in neurons may provide vital insights into how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66cf5700bbfa8545d915e688d50a655
https://escholarship.org/uc/item/7984b8kk
https://escholarship.org/uc/item/7984b8kk
Publikováno v:
Autophagy
Autophagy, vol 18, iss 1
Autophagy, vol 18, iss 1
Parkinson disease remains a debilitating neurodegenerative disorder, despite the discovery of multiple causative genes that account for familial forms. Prominent among these are PRKN/Parkin and PINK1, whose protein products participate in mitochondri
Autor:
Eric J. Huang, Zak Doric, Hiromi Sesaki, Amandine Berthet, Steve Finkbeiner, Ivy Hsieh, Jayanta Debnath, Mai K. Nguyen, Rebecca Fang, Ken Nakamura, Huihui Li, Julia Margulis, Danielle M. Jorgens
Publikováno v:
Science Advances
Time-lapse imaging delineates the mitochondrial life cycle in neurons regulated by PINK1 and Parkin.
Altered mitochondrial quality control and dynamics may contribute to neurodegenerative diseases, including Parkinson’s disease, but we underst
Altered mitochondrial quality control and dynamics may contribute to neurodegenerative diseases, including Parkinson’s disease, but we underst
Autor:
Lauren Y. Shields, Zak Doric, Hwajin Kim, Meredith E. K. Calvert, Ken Nakamura, Dominik Haddad, Huihui Li, Kevin Nguyen, T. Michael Gill, Keith A. Vossel
Alterations in mitochondrial fission may contribute to the pathophysiology of several neurodegenerative diseases, including Alzheimer’s disease (AD). However, we understand very little about the normal functions of fission, or how fission disruptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca093d7ebf11e407d87f2bf33240f3b2
Autor:
Ken Nakamura, Kevin Nguyen, Dominik Haddad, Hwajin Kim, Keith A. Vossel, Meredith E. K. Calvert, Lauren Y. Shields, Zak Doric, T. Michael Gill, Joseph H. Garcia, Huihui Li
Publikováno v:
The Journal of Biological Chemistry
Alterations in mitochondrial fission may contribute to the pathophysiology of several neurodegenerative diseases, including Alzheimer’s disease (AD). However, we understand very little about the normal functions of fission or how fission disruption