Reduced Effectiveness and Comparable Safety in Biweekly vs. Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trial

Autor: Chengjun Sun, Biao Lu, Yu Liu, Yaqin Zhang, Haiyan Wei, Xu Hu, Pei Hu, Qian Zhao, Yanling Liu, Kan Ye, Kan Wang, Zaiyan Gu, Zheng Liu, Jin Ye, Hongxiao Zhang, Hong Zhu, Zhihong Jiang, Yanjie Liu, Naijun Wan, Chengming Yan, Jianying Yin, Lirong Ying, Feng Huang, Qingjin Yin, Li Xi, Feihong Luo, Ruoqian Cheng

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

ContextLong-acting recombinant human growth hormone (rhGH) has transformed growth hormone deficiency (GHD) treatment. However, the possibility and rationality for flexible time regimen are pending.ObjectiveWe studied the efficacy of biweekly versus w

Externí odkaz: https://doaj.org/article/342716233f3f4e22bd958dab3aed79f3

Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study

Autor: Ling Hou, Ke Huang, Chunxiu Gong, Feihong Luo, Haiyan Wei, Liyang Liang, Hongwei Du, Jianping Zhang, Yan Zhong, Ruimin Chen, Xinran Chen, Jiayan Pan, Xianjiang Jin, Ting Zeng, Wei Liao, Deyun Liu, Dan Lan, Shunye Zhu, Zhiya Dong, Huamei Ma, Yu Yang, Feng Xiong, Ping Lu, Shengquan Cheng, Xuefan Gu, Runming Jin, Yu Liu, Jinzhun Wu, Xu Xu, Linqi Chen, Qin Dong, Hui Pan, Zhe Su, Lijun Liu, Xiaoming Luo, Shining Ni, Zhihong Chen, Yuhua Hu, Chunlin Wang, Jing Liu, Li Liu, Biao Lu, Xinli Wang, Yunfeng Wang, Fan Yang, Manyan Zhang, Lizhi Cao, GeLi Liu, Hui Yao, Yaqin Zhan, Mingjuan Dai, Guimei Li, Li Li, Yanjie Liu, Kan Wang, Yanfeng Xiao, Xingxing Zhang, Junhua Dong, Zaiyan Gu, Lirong Ying, Feng Huang, Yanling Liu, Zheng Liu, Jin Ye, Dongmei Zhao, Xu Hu, Zhihong Jiang, Kan Ye, Hong Zhu, Shaoke Chen, Xiaobo Chen, Naijun Wan, Zhuangjian Xu, Qingjin Yin, Hongxiao Zhang, Xiaodong Huang, Jianying Yin, Huifeng Zhang, Pin Li, Ping Yin, Junfen Fu, XiaoPing Luo

Publikováno v: The Journal of Clinical Endocrinology & Metabolism.

Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f8c92d40e43a1d4b05cfcc7aaf84134
https://doi.org/10.1210/clinem/dgad039

The prevalence of premature thelarche in girls and gynecomastia in boys and the associated factors in children in Southern China

Autor: Zhifeng Yang, Xiding Cai, Lanqiu Lv, Xiaohua Xu, Jinliang Xu, Jianwei Zhang, Xianjiang Jin, Lifang Liu, Junfen Fu, Xinxian Shu, Zaiyan Gu

Publikováno v: BMC Pediatrics, Vol 19, Iss 1, Pp 1-7 (2019)
BMC Pediatrics

Background To investigate the prevalence and risk factors of premature thelarche (PT) in girls and gynecomastia (GM) in boys in Southern China. Methods We conducted a cross-sectional study of preschool children across 9 cities in Zhejiang province. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f4de75cf6c4b51319b4a70f9606d2c
https://doi.org/10.1186/s12887-019-1426-6