Stereotactic Radiation Therapy for De Novo Head and Neck Cancers: A Systematic Review and Meta-Analysis

Autor: Nauman H. Malik, MD, Michael S. Kim, MD, Hanbo Chen, MD, Ian Poon, MD, Zain Husain, MD, Antoine Eskander, MD, Gabriel Boldt, MLIS, Alexander V. Louie, MD, PhD, Irene Karam, MD

Publikováno v: Advances in Radiation Oncology, Vol 6, Iss 1, Pp 100628- (2021)

Purpose: Stereotactic body radiation therapy (SBRT) for de novo (previously untreated) head and neck cancers (HNCs) is increasingly being used in medically unfit patients. A systematic review of SBRT was conducted for previously untreated HNCs. Metho

Externí odkaz: https://doaj.org/article/30c8926523364620aa5c82603e592a5b

Reply to K. Yokoyama et al.

Autor: Noel CW; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Sutradhar R; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Zhao H; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Delibasic V; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Forner D; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Irish JC; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Kim J; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Husain Z; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Mahar A; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Karam I; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Enepekides DJ; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Chan KKW; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Singh S; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Hallet J; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Coburn NG; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Eskander A; Christopher W. Noel, MD, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Rinku Sutradhar, PhD, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada; Haoyu Zhao, MPH, and Victoria Delibasic, BHSc, ICES, Toronto, ON, Canada; David Forner, MD, MSc, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS, Canada; Jonathan C. Irish, MD, MSc, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; John Kim, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Zain Husain, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Alyson Mahar, PhD, Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Irene Karam, MD, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Danny J. Enepekides, MD, MPH, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Kelvin K. W. Chan, MD, MSc, PhD, and Simron Singh,MD, MPH, Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Julie Hallet, MD, MSc, and Natalie G. Coburn, MD, MPH, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Antoine Eskander, MD, ScM, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ICES, Toronto, ON, Canada, Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2021 Jul 20; Vol. 39 (21), pp. 2417-2419. Date of Electronic Publication: 2021 May 05.