Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Zailian Lu"'
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Abstract CT263: A phase Ib dose-expansion study of porustobart, an anti-CTLA-4 heavy chain only monoclonal antibody, in combination with toripalimab in patients with advanced high-grade neuroendocrine neoplasms (NENs)
Autor: Ming Lu, Panpan Zhang, Lin Shen, Kai Chen, Jianwei Yang, Lijie Song, Humphrey Gardner, Kedan Lin, Luyin Ding, Shuai Zhao, Yuan Geng, Jie Ding, Zailian Lu, Yedong Wang
Publikováno v: Cancer Research. 83:CT263-CT263
Background: Porustobart (HBM4003) is a fully human heavy chain only monoclonal antibody targeting CTLA-4. In addition to blocking the CTLA-4 pathway, porustobart was engineered to deplete Treg cells by enhanced antibody-dependent cellular cytotoxicit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f0059bcf8fe05ce39d633fa2e58ca9d
https://doi.org/10.1158/1538-7445.am2023-ct263
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3
The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
Autor: Zhiyun Ye, Chen-Song Zhang, Zailian Lu, Bin Jiang, Huiling Guo, Terytty Yang Li, Yongying Peng, Sheng-Cai Lin, Jiahuai Han, Huiyong Yin, Qing Liu, Shu-Yong Lin, Yu Liang, Mengqi Li, Guili Lian, Yu-Qing Wu, Jia-Wei Wu, Mingjiang Zhu, Yalin Zhang, Zhenyu Yin
Publikováno v: Cell Metabolism. 20(3):526-540
SummaryAMPK and mTOR play principal roles in governing metabolic programs; however, mechanisms underlying the coordination of the two inversely regulated kinases remain unclear. In this study we found, most surprisingly, that the late endosomal/lysos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5047b5472937e11f2c5e4c98c18b73b
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4
A β-Catenin-Independent Dorsalization Pathway Activated by Axin/JNK Signaling and Antagonized by Aida
Autor: Zhiyun Ye, Bo Xiong, Zhen Xu, Shu-Yong Lin, Hai-Meng Zhou, Anming Meng, Ying Cao, Sheng-Cai Lin, Min Zhang, Jiahuai Han, Ying Han, Siu Chiu Chan, Zailian Lu, Wen Luo, Yanning Rui
Publikováno v: Developmental Cell. 13(2):268-282
Axin is a scaffold protein that controls multiple important pathways, including the canonical Wnt pathway and JNK signaling. Here we have identified an Axin-interacting protein, Aida, which blocks Axin-mediated JNK activation by disrupting Axin homod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7577be9aa3415f7c0e78035ac2323e14
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5
Axin determines cell fate by controlling the p53 activation threshold after DNA damage
Autor: Zailian Lu, Ka Ruan, Huiling Guo, Shu-Yong Lin, Jiahuai Han, Guili Lian, Yanhai Wang, Sheng-Cai Lin, Zhiyun Ye, Xuan Wang, Qinxi Li
Publikováno v: Nature cell biology. 11(9)
Cells can undergo either cell-cycle arrest or apoptosis after genotoxic stress, based on p53 activity(1-6). Here we show that cellular fate commitment depends on Axin forming distinct complexes with Pirh2, Tip60, HIPK2 and p53. In cells treated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44045c30835a88453b444792593a23b
https://pubmed.ncbi.nlm.nih.gov/19731416
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6
Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling
Autor: Ka Ruan, Yanning Rui, Zhiyun Ye, Zailian Lu, Ying He, Sheng-Cai Lin, Wei Liu, Ying Han, Yanhai Wang, Qinxi Li, Huizhe Huang, Anming Meng, Boon Chuan Low
Publikováno v: The Journal of biological chemistry. 283(19)
Axin plays an architectural role in many important signaling pathways that control various aspects of development and tumorigenesis, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades. It is en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da4e7342cafe2d45033bba509f7327e
https://pubmed.ncbi.nlm.nih.gov/18316368
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8
Akademický článek
Axin determines cell fate by controlling the p53 activation threshold after DNA damage.
Autor: Qinxi Li, Shuyong Lin, Xuan Wang, Guili Lian, Zailian Lu, Huiling Guo, Ka Ruan, Yanhai Wang, Zhiyun Ye, Jiahuai Han, Sheng-Cai Lin
Publikováno v: Nature Cell Biology; Sep2009, Vol. 11 Issue 9, p1128-1134, 7p, 6 Color Photographs, 2 Black and White Photographs, 3 Diagrams, 5 Graphs
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9
Akademický článek
Protein Encoded by the AxinFu Allele Effectively Down-regulates Wnt Signaling but Exerts a Dominant Negative Effect on c-Jun N-terminal Kinase Signaling.
Autor: Zailian Lu1, Wei Liu2, Huizhe Huang1, Ying He1, Ying Han1, Yanning Rui1, Yanhai Wang1, Qinxi Li1, Ka Ruan1, Zhiyun Ye1, Boon Chuan Low3, Anming Meng4, Sheng-Cai Lin1 Iinsc@xmu.edu.cn
Publikováno v: Journal of Biological Chemistry. 5/9/2008, Vol. 283 Issue 19, p13132-13139. 8p. 3 Color Photographs, 15 Black and White Photographs, 3 Diagrams, 6 Graphs.
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