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pro vyhledávání: '"Zaika, Alex"'
Publikováno v:
In BBA - Reviews on Cancer 2001 1552(2):47-59
Publikováno v:
In FEBS Letters 2001 488(3):110-115
Since inhibitory interactions of two proteins often lead to their stabilization, we asked whether !Np73 can affect TAp73 protein levels. We show here that deltaNp73 isoforms indeed stabilise TAp73 proteins but, in doing so, inhibit their transactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2a50984700c9429946578c83600f3c04
https://www.bib.irb.hr/206279
https://www.bib.irb.hr/206279
Since inhibitory interactions of two proteins often lead to their stabilization, we asked whether !Np73 can affect TAp73 protein levels. We show here that deltaNp73 isoforms indeed stabilise TAp73 proteins but, in doing so, inhibit their transactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::a426c14a9adb289bb799cd51f72aadf0
https://www.bib.irb.hr/206341
https://www.bib.irb.hr/206341
The TP53 family member TP73 generates transactivating forms (TAp73) as well as a number of N-terminally truncated, transactivation-deficient transdominant isoforms. There are three such isoforms called DNp73, Ex2p73 and Ex2/3p73. Importantly, DNp73,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::370657d0f40a957f640991858d0be047
https://www.bib.irb.hr/206311
https://www.bib.irb.hr/206311
Autor:
Zaika, Alex I., Slade, Neda, Erster, Susan, Sansome, Christine, Joseph, Troy W., Pearl, Michael, Chalas, Eva, Moll, Ute M.
p73 has significant homology to p53. However, tumor-associated up-regulation of p73 and genetic data from human tumors and p73-deficient mice exclude a classical Knudson-type tumor suppressor role. We report that the human TP73 gene generates an NH2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::f8b1872ca191ba320dcd89ff9c9ce8c8
https://www.bib.irb.hr/206258
https://www.bib.irb.hr/206258
Akademický článek
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Publikováno v:
FASEB Journal; Sep2003, Vol. 17 Issue 12, p1622, 9p, 14 Color Photographs, 1 Diagram