Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Zaihui, Zhang"'
Autor:
Katharina Köchl, Tobias Schopper, Vedat Durmaz, Lena Parigger, Amit Singh, Andreas Krassnigg, Marco Cespugli, Wei Wu, Xiaoli Yang, Yanchong Zhang, Welson Wen-Shang Wang, Crystal Selluski, Tiehan Zhao, Xin Zhang, Caihong Bai, Leon Lin, Yuxiang Hu, Zhiwei Xie, Zaihui Zhang, Jun Yan, Kurt Zatloukal, Karl Gruber, Georg Steinkellner, Christian C. Gruber
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Treatment of COVID-19 with a soluble version of ACE2 that binds to SARS-CoV-2 virions before they enter host cells is a promising approach, however it needs to be optimized and adapted to emerging viral variants. The computational workflow p
Externí odkaz:
https://doaj.org/article/09584ce721704992ad8d2da8bc68bc58
Autor:
Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb, Charles J. Cohen
Divalent metal transporter 1 (DMT1) cotransports ferrous iron and protons and is the primary mechanism for uptake of non-heme iron by enterocytes. Inhibitors are potentially useful as therapeutic agents to treat iron overload disorders such as heredi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a8fd089f5e95fb80b88ed63e8dd321
https://doi.org/10.1101/2022.09.01.506269
https://doi.org/10.1101/2022.09.01.506269
Autor:
Xianyan Hu, Rong Zou, Zaihui Zhang, Jia Ji, Jiqiang Li, Xin-Yu Huo, Di Liu, Man-Xi Ge, Meng-Ke Cui, Ming-Zhi Wu, Zhao-Peng Li, Qingchen Wang, Xiaoli Zhang, Zai-Rong Zhang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1866:194937
Autor:
Yubin Ge, Hong Liu, Rick Li, German Novakovskiy, Jun Yan, Depei Wu, Florian Kuchenbauer, Min Chen, Katharina Rothe, Zaihui Zhang, Xiuyan Zhang, Sung-Eun Nam, Yun Zhao, Irina A Maksakova, Xiaojia Niu, Xiaoyan Jiang, Yehyeon Ahn, Arefeh Rouhi, Shenshen Lai, Wyeth W. Wasserman, Calvin K. Yip, Sarah Grasedieck, Hong Zhang
Publikováno v:
Blood. 137:3641-3655
The abundance of genetic abnormalities and phenotypic heterogeneities in acute myeloid leukemia (AML) poses significant challenges to the development of improved treatments. Here, we demonstrated that a key growth arrest-specific gene 6/AXL axis is h
Autor:
Jacob T. Andring, Zaihui Zhang, Mam Y. Mboge, Srishti Singh, Susan C. Frost, Robert McKenna, Jacob Combs, Alyssa Wolff, Chingkuang Tu
Publikováno v:
J Med Chem
Carbonic anhydrase IX (CAIX) is considered a target for therapeutic intervention in solid tumors. In this study, the efficacy of the inhibitor, 4-(3-(2,4-difluorophenyl)-oxoimidazolidin-1-yl)benzenesulfonamide (SLC-149), is evaluated on CAIX and a CA
Autor:
Daniel J. Renouf, Zaihui Zhang, Stephen Chia, Madhu Singh, Paul C. McDonald, Philippe L. Bedard, Liren Tang, Quincy Chu, Shoukat Dedhar, Michael Lyle, Claudiu T. Supuran
Publikováno v:
American Journal of Clinical Oncology
Supplemental Digital Content is available in the text.
Objectives: SLC-0111 is an ureido-substituted benzenesulfonamide small molecule inhibitor of carbonic anhydrase IX. The objectives of this first-in-human Phase 1 study were to determine the
Objectives: SLC-0111 is an ureido-substituted benzenesulfonamide small molecule inhibitor of carbonic anhydrase IX. The objectives of this first-in-human Phase 1 study were to determine the
Autor:
Sung-Eun Nam, Rick Li, Calvin K. Yip, Min Chen, Yun Zhao, German Novakovskiy, Jun Yan, Depei Wu, Xiaoyan Jiang, Xiuyan Zhang, Shenshen Lai, Yubin Ge, Xiaojia Niu, Zaihui Zhang, Hong Zhang, Wyeth W. Wasserman, Hong Liu, Katharina Rothe, Yehyeon Ahn
Publikováno v:
Experimental Hematology. 88:S76-S77
Acute myeloid leukemia (AML) is an aggressive haematological cancer characterized phenotypically by the rapid clonal growth of myeloid cells and an accumulation of immature blasts. Although major progress has been made in identifying different geneti
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(18)
Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most commonly employed amide isosteres in drug design aiming at improving potency and selectivity, optimizing physicochemic
Autor:
Paul C. McDonald, Philippe L. Bedard, Liren Tang, Zaihui Zhang, Qunicy Chu, Daniel J. Renouf, Michael Lyle, Madhu Singh, Stephen Chia, Shoukat Dedhar, Claudiu T. Supuran
Publikováno v:
Cancer Research. 80:CT161-CT161
Carbonic anhydrase IX (CAIX) is a cell surface, HIF-1A-inducible enzyme that is highly expressed in many solid tumors, is considered to be an endogenous marker of hypoxia and is a prominent biomarker of poor patient prognosis. In contrast, CAIX expre
Autor:
Rostam Namdari, Jianmin Fu, Brian K. Hubbard, Kuldip Khakh, Suzie Ferreira, Michael D. Winther, Zaihui Zhang, Vandna Raina, Duanjie Hou, Natalie Dales, David G. McLaren, Leslie G. Ratkay, Pokrovskaia Natalia, Shaoyi Sun, Monica Mork
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:526-531
We discovered a series of novel and potent thiazolylpyridinone-based SCD1 inhibitors based on a 2-aminothiazole HTS hit by replacing the amide bond with a pyridinone moiety. Compound 19 demonstrated good potency against SCD1 in vitro and in vivo. The