Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Zai-jun Zhang"'
Autor:
Qian Liu, Xin Wang, Yu Hu, Jun-Ning Zhao, Chun-Hui Huang, Ting Li, Bing-Ge Zhang, Ye He, Yan-Qing Wu, Zai-Jun Zhang, Guo-Ping Wang, Gong-Ping Liu
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102697- (2023)
Increased tau acetylation at K274 and K281 has been observed in the brains of Alzheimer's disease (AD) patients and animal models, and mitochondrial dysfunction are noticeable and early features of AD. However, the effect of acetylated tau on mitocho
Externí odkaz:
https://doaj.org/article/94a8882b6abf4fe0a6a1b6442f7ed766
Autor:
Xiao-Bin Liu, Feng Liu, Yi-Yao Liang, Gang Yin, Hui-Jun Zhang, Xue-Song Mi, Zai-Jun Zhang, Kwok-Fai So, Ang Li, Ying Xu
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 10, Pp 2109-2120 (2021)
Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal disease
Externí odkaz:
https://doaj.org/article/4b1422e7fe3944b38dffb9213ce928c7
Autor:
Cheng-you Zheng, Bao-jian Guo, Wei Cai, Wei Cui, Shing-hung Mak, Yu-qiang Wang, Simon Ming-yuen Lee, Yi-fan Han, Zai-jun Zhang
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 8, Pp 1339-1346 (2016)
Rasagiline, a monoamine oxidase-B inhibitor, and bis(propyl)-cognitin (B3C), a novel dimer are reported to be neuroprotective. Herein, the synergistical neuroprotection produced by rasagiline and B3C was investigated in 1-methyl-4-phenyl-1,2,3,6-tetr
Externí odkaz:
https://doaj.org/article/d4fc58dd84c34d20828aee15c6475cfc
Autor:
Yibo Qu, Guo-Dong Chen, Xiao-Xia Wang, Xin-Sheng Yao, Jian Zou, Rong-Rong He, Hao Gao, Kwok-Fai So, Zai-Jun Zhang, Huan Zhao
Publikováno v:
Chemical Communications. 55:6221-6224
Triangeliphthalides A-D (1-4), four novel phthalide trimers with two new linkage styles, were isolated from Angelica sinensis, together with two related phthalide dimers (5-6). Their structures including absolute configurations were determined. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa43840343c161953552b59300e76c9
https://doi.org/10.1039/c9cc02681a
https://doi.org/10.1039/c9cc02681a
Publikováno v:
Functional plant biology : FPB. 31(4)
The key role of mitochondria in the integration of apoptosis and oxidative stress in mammals has been documented. In plants, mitochondria are implicated in cytoplasmic male sterility (CMS), programmed cell death (PCD), and oxidative stress. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a439ba8ed89e7220df8a3b149069ba8
https://pubmed.ncbi.nlm.nih.gov/32688907
https://pubmed.ncbi.nlm.nih.gov/32688907
Autor:
Jing Yan Tang, Shang Li, Zhen Hua Li, Zai Jun Zhang, Guang Hu, Lorita Chi Veng Cheang, Deepa Alex, Maggie Pui Man Hoi, Yiu Wa Kwan, Shun Wan Chan, George Pak Heng Leung, Simon Ming Yuen Lee
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11822 (2010)
BACKGROUND: Angiogenesis plays an important role in a wide range of physiological processes, and many diseases are associated with the dysregulation of angiogenesis. Radix Astragali is a Chinese medicinal herb commonly used for treating cardiovascula
Externí odkaz:
https://doaj.org/article/31444afead2642cc9001352227ef51e6
Autor:
Xiaopeng Luo, Zai-Jun Zhang, Yankun Yu, Ying Xu, Seeram Ramakrishna, Kwok-Fai So, Huisu Wu, Zongqin Xiang, Yuqiang Wang
Publikováno v:
Journal of Neurochemistry. 141:373-386
Adding a free radical-scavenging nitrone moiety on tetramethylpyrazine, we have previously synthesized a chemical named 2-[[(1,1-dimethylethyl)oxidoimino]-methyl]-3,5,6- trimethylpyrazine (tetramethylpyrazine nitrone, or TBN) and proved its neuro-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a28d93621115392d3b977b56cb0126
https://doi.org/10.1111/jnc.13970
https://doi.org/10.1111/jnc.13970
Autor:
Gao Xiao Zhang, Karl Wah Keung Tsim, Wei Cui, Da Ping Xu, Guo Lian Tan, Wei Cai, Jin Zhao Wang, Yu Qiang Wang, Zai Jun Zhang, Cheng Long, Hai Yun Chen, Ye Wei Sun, Pei Yu, Yifan Han
Publikováno v:
Journal of Molecular Neuroscience. 56:977-987
Neurodegenerative disorders are one of the leading causes of death among the elderly. Therapeutic approaches with a single target have proven unsuccessful in treating these diseases. Structural combination of multi-functional compounds may lead to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d70e5f1e00d8a8139b6fdbd25456be6
https://doi.org/10.1007/s12031-015-0566-x
https://doi.org/10.1007/s12031-015-0566-x
Autor:
Zai Jun Zhang, Ying Zheng, Lun Qing Zhang, Cheong Meng Chong, Simon Ming-Yuen Lee, Bao Jian Guo, Fei Sa, Pui Man Hoi, Sai Li
Publikováno v:
Neuroscience Letters. 593:7-12
Dibenzocyclooctadiene lignans represent a unique group of natural chemical structures, are considered as protectants against neuronal cell death and cognitive impairment in neurological disorders. Among the family of dibenzocyclooctadiene lignan anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7b5509d05f461dbb7486d319574a0c
https://doi.org/10.1016/j.neulet.2015.03.016
https://doi.org/10.1016/j.neulet.2015.03.016
Autor:
Yu Qiang Wang, Simon Ming-Yuen Lee, Zai Jun Zhang, Yifan Han, Kun Zhang, Ye Wei Sun, Pui Man Hoi, Da Ping Xu, Bao Jian Guo
Publikováno v:
Neurochemistry International. 78:76-85
Introduction The natural product tetramethylpyrazine (TMP) has a variety of biologic activities, including neuroprotection. Nitrones are powerful free radical scavengers. We have designed and synthesized a TMP derivative, TN-2, which is armed with tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1416d6e7aa68b693045d388d736fcd71
https://doi.org/10.1016/j.neuint.2014.09.001
https://doi.org/10.1016/j.neuint.2014.09.001