Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zahra Sadrai"'
Autor:
Jing Hua, Negar Pirmadjid, William Stevenson, Reza Dana, Thomas H. Dohlman, Maryam Tahvildari, Zahra Sadrai, Sunil K. Chauhan, Takenori Inomata, Narghes Calcagno
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The graft site microenvironment has a profound effect on alloimmunity and graft survival. We aimed to study the kinetics and phenotype of trafficking antigen-presenting cells (APC) to the draining lymph nodes (DLNs) in a mouse model of cornea
Autor:
Wungrak Choi, Yu Jeong Byun, Amir Reza Hajrasouliha, Joon H. Lee, Zahra Sadrai, Hyemi Noh, Eunae Jeong, Eun-Ju Chang, Hyung Keun Lee
Publikováno v:
Journal of leukocyte biology. 97(2)
Although corneal allotransplantation is performed in the immune-privileged cornea, many grafts are still rejected after transplantation. This study examined the role of chemokine receptor D6 expression in a corneal allograft rejection, investigated t
Autor:
Sunil K. Chauhan, William Stevenson, Reza Dana, Shilpa Kodati, Jing Hua, Zahra Sadrai, Jing-Feng Huang
Publikováno v:
Cornea. 33(2)
Purpose To determine the effects of topical Janus kinase inhibition on ocular surface inflammation and immunity. Methods Ophthalmic 0.003% tofacitinib (CP-690,550) was administered topically to inhibit Janus kinase activation at the ocular surface. M
Autor:
Thomas H. Dohlman, Masahiro Omoto, Shilpa Kodati, Yihe Chen, Sunil K. Chauhan, Zahra Sadrai, Reza Dana, Jing Hua
Publikováno v:
Investigative ophthalmologyvisual science. 54(6)
Purpose Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are unknown. The purpose of this study
Autor:
Shilpa Kodati, Zahra Sadrai, Daniel R. Saban, Sunil K. Chauhan, Chris S. Schaumburg, Reza Dana, Hyun Soo Lee, William Stevenson, Michael E. Stern, Yihe Chen
Publikováno v:
Investigative ophthalmologyvisual science. 54(4)
Purpose A majority of experimental data on dry eye disease (DED) immunopathogenesis have been derived from a murine model of DED that combines desiccating environmental stress with systemic muscarinic acetylcholine receptor (mAChR) inhibition. Howeve
Autor:
Hiroki Ueno, Sunil K. Chauhan, Giulio Ferrari, Amir Reza Hajrasouliha, Reza Dana, Zahra Sadrai
Publikováno v:
Investigative ophthalmologyvisual science. 54(1)
PURPOSE To evaluate the regulatory cross-talk of the vascular and neural networks in the cornea. METHODS b-FGF micropellets (80 ng) were implanted in the temporal side of the cornea of healthy C57Bl/6 mice. On day 7, blood vessels (hemangiogenesis) a
Autor:
Reza Dana, Jing Hua, Thomas H. Dohlman, William G. Stevenson, Sunil K. Chauhan, Zahra Sadrai, Andre Okanobo, Francisco Amparo, Yihe Chen
Publikováno v:
Investigative ophthalmologyvisual science. 53(7)
To determine the effect of phosphodiesterase type-4 (PDE4) inhibition on IL-17-associated immunity in experimental dry eye disease (DED).Murine DED was induced, after which a PDE4 inhibitor (cilomilast), dexamethasone, cyclosporine, or a relevant veh
Publikováno v:
Cornea. 31(7)
PURPOSE To study the spatial variances in ligand expression and angiogenic effect in response to the inflammatory response induced by basic fibroblast growth factor (b-FGF). METHODS b-FGF micropellets (80 ng) were implanted in the temporal side of th
Autor:
Sunil K. Chauhan, Amir Reza Hajrasouliha, Reza Dana, Zahra Sadrai, Takaaki Hattori, Toshinari Funaki
Publikováno v:
Investigative ophthalmologyvisual science. 53(3)
The Eye Bank Association of America reports that >40,000 corneal transplants are performed annually in the United States.1 However, survival of corneal transplants is severely compromised when grafts are placed in vascularized and inflamed so-called
Publikováno v:
Investigative ophthalmologyvisual science. 52(12)
Topical application of drug is the preferred method of administration to the cornea, ocular surface, and anterior segment, because achieving a high therapeutic level of medicine in these tissues can often be feasible without imposing systemic side ef