Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Zahra Razook"'
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Autor:
Myo T. Naung, Elijah Martin, Wilson Wong, Zahra Razook, Digjaya Utama, Andrew J. Guy, Shannon Takala Harrison, Alan F. Cowman, Enmoore Lin, Benson Kiniboro, Moses Laman, Ivo Mueller, Alyssa E. Barry
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
Plasmodium falciparum Reticulocyte Binding Protein Homologue (RH5), a leading malaria vaccine candidate, is essential for erythrocyte invasion by the parasite, interacting with the human host receptor, basigin. RH5 has a small number of polymorphisms
Externí odkaz:
https://doaj.org/article/9c0eded36cbd4ed89c86f1699d2705be
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Dulcie Lautu-Gumal, Zahra Razook, Tamarah Koleala, Elma Nate, Samuel McEwen, Diana Timbi, Manuel W. Hetzel, Evelyn Lavu, Nakapi Tefuarani, Leo Makita, James Kazura, Ivo Mueller, William Pomat, Moses Laman, Leanne J. Robinson, Alyssa E. Barry
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 188-193 (2021)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated with delayed parasite clearance hav
Externí odkaz:
https://doaj.org/article/198619d3abfe4e2bbb6d7c0403e93cc4
Autor:
Katherine O’Flaherty, Win Han Oo, Sophie G. Zaloumis, Julia C. Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R. Drew, Zahra Razook, Alyssa E. Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A. Simpson, James G. Beeson, Paul A. Agius, Freya J. I. Fowkes
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health volunteers (VHVs) reporting the results of rapid diagnostic tests (RDTs), known to miss many asymptomatic infection
Externí odkaz:
https://doaj.org/article/d938c3430c7145499056a612335bdf88
Autor:
Abebe A. Fola, Eline Kattenberg, Zahra Razook, Dulcie Lautu-Gumal, Stuart Lee, Somya Mehra, Melanie Bahlo, James Kazura, Leanne J. Robinson, Moses Laman, Ivo Mueller, Alyssa E. Barry
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background Genomic surveillance of malaria parasite populations has the potential to inform control strategies and to monitor the impact of interventions. Barcodes comprising large numbers of single nucleotide polymorphism (SNP) markers are
Externí odkaz:
https://doaj.org/article/47c2a8a7586e429bb5e17b5cb1a7b59f
Autor:
Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J. Rogerson, Moses Laman, Daniel Tisch, Ingrid Felger, James W. Kazura, Ivo Mueller, Leanne J. Robinson
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Introduction As malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falciparum relative to Plasmodium vivax and identifying key drivers of ongoing transmission is essential to guide futur
Externí odkaz:
https://doaj.org/article/1d960c0581e9451eb49696bc17db4088
Autor:
Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha, Freya J I Fowkes
Publikováno v:
PLoS Medicine, Vol 17, Iss 8, p e1003177 (2020)
BackgroundThe World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of public health campaigns. We aimed to quantify the effectiveness of repellent distributed by the village health volunteer (VH
Externí odkaz:
https://doaj.org/article/8c22b44404e04e7db684078250bb686f
Autor:
Dawson B. Ling, William Nguyen, Oliver Looker, Zahra Razook, Kirsty McCann, Alyssa E. Barry, Christian Scheurer, Sergio Wittlin, Hayley E. Bullen, Brendan S. Crabb, Brad E. Sleebs, Paul R. Gilson
With resistance increasing to current antimalarial medicines, there is an urgent need to discover new drug targets and to develop new medicines against these targets. We therefore screened the Open Global Health Library of Merck KGaA, Darmstadt, Germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79da886bdfa82ef02058e8e17100e95d
https://doi.org/10.1101/2023.04.25.538349
https://doi.org/10.1101/2023.04.25.538349