Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zahra, Timsah"'
Autor:
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz:
https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
Autor:
Amira Bekdash, Manal Darwish, Zahra Timsah, Elias Kassab, Hadi Ghanem, Vicky Najjar, Marwan Ghosn, Selim Nasser, Hiba El-Hajj, Ali Bazerbachi, Shihui Liu, Stephen H. Leppla, Arthur E. Frankel, Ralph J. Abi-Habib
Publikováno v:
Translational Oncology, Vol 8, Iss 5, Pp 347-357 (2015)
In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal toxi
Externí odkaz:
https://doaj.org/article/e3a546f6ff5d4a54b4c56054715b8842
Autor:
Elias Kassab, Manal Darwish, Zahra Timsah, ShiHui Liu, Stephen H. Leppla, Arthur E. Frankel, Ralph J. Abi-Habib
Publikováno v:
Translational Oncology, Vol 6, Iss 1, Pp 25-32 (2013)
In this study, we attempt to target the mitogen-activated protein kinase (MAPK) pathway in acute myeloid leukemia (AML) cells using a recombinant anthrax lethal toxin (LeTx). LeTx consists of protective antigen (PrAg) and lethal factor (LF). PrAg bin
Externí odkaz:
https://doaj.org/article/dedcb1e311af452abb41149b646d6a01
Autor:
Eleni Kyriakopoulou, Liza Berrout, Margaret A. Knowles, Klaus Suhling, Carolyn D. Hurst, Peter M. Zygmunt, Michael Shires, Simon Davies, Sujanitha Umamaheswaran, Lavanya Moparthi, Nikita Gamper, Xin Hu, Stephen P. Muench, Thomas Hall, N. Joan Abbott, Mihai Gagea, Alexandra S. Hogea, Yurema Teijeiro Gonzalez, Mihaela Lorger, Chris Peers, Cristina-Elena Ivan, Kenneth G. MacLeod, Zahra Timsah, Laura Wesley, Jonathan Berrout, Jacobo Elies Gomez, Iain W. Manfield, Neil O. Carragher, John F. Boyle, George A. Calin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Berrout, J, Kyriakopoulou, E, Moparthi, L, S. Hogea, A, Berrout, L, Ivan, C, Lorger, M, Boyle, J, Peers, C, Muench, S, Elies Gomez, J, Hu, X, Hurst, C, Hall, T, Umamaheswaran, S, Wesley, L, Gagea, M, Shires, M, Manfield, I, A. Knowles, M, Davies, S, Suhling, K, Teijeiro Gonzalez, Y, Carragher, N, Macleod, K, Abbott, N J, A. Calin, G, Gamper, N, M. Zygmunt, P & Timsah, Z 2017, ' TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ', Nature Communications . https://doi.org/10.1038/s41467-017-00983-w
Berrout, J, Kyriakopoulou, E, Moparthi, L, Hogea, A S, Berrout, L, Ivan, C, Lorger, M, Boyle, J, Peers, C, Muench, S, Gomez, J E, Hu, X, Hurst, C, Hall, T, Umamaheswaran, S, Wesley, L, Gagea, M, Shires, M, Manfield, I, Knowles, M A, Davies, S, Suhling, K, Gonzalez, Y T, Carragher, N, Macleod, K, Abbott, N J, Calin, G A, Gamper, N, Zygmunt, P M & Timsah, Z 2017, ' TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ', Nature Communications, vol. 8, no. 1, 983, pp. 1-15 . https://doi.org/10.1038/s41467-017-00983-w
Nature Communications
Berrout, J, Kyriakopoulou, E, Moparthi, L, S. Hogea, A, Berrout, L, Ivan, C, Lorger, M, Boyle, J, Peers, C, Muench, S, Elies Gomez, J, Hu, X, Hurst, C, Hall, T, Umamaheswaran, S, Wesley, L, Gagea, M, Shires, M, Manfield, I, A. Knowles, M, Davies, S, Suhling, K, Teijeiro Gonzalez, Y, Carragher, N, Macleod, K, Abbott, N J, A. Calin, G, Gamper, N, M. Zygmunt, P & Timsah, Z 2017, ' TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ', Nature Communications . https://doi.org/10.1038/s41467-017-00983-w
Berrout, J, Kyriakopoulou, E, Moparthi, L, Hogea, A S, Berrout, L, Ivan, C, Lorger, M, Boyle, J, Peers, C, Muench, S, Gomez, J E, Hu, X, Hurst, C, Hall, T, Umamaheswaran, S, Wesley, L, Gagea, M, Shires, M, Manfield, I, Knowles, M A, Davies, S, Suhling, K, Gonzalez, Y T, Carragher, N, Macleod, K, Abbott, N J, Calin, G A, Gamper, N, Zygmunt, P M & Timsah, Z 2017, ' TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ', Nature Communications, vol. 8, no. 1, 983, pp. 1-15 . https://doi.org/10.1038/s41467-017-00983-w
Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464a839bb442843b4d981ad626e44d93
http://link.springer.com/article/10.1038/s41467-017-00983-w
http://link.springer.com/article/10.1038/s41467-017-00983-w
Autor:
Hiba El-Hajj, Elias Kassab, Zahra Timsah, Arthur E. Frankel, Selim M. Nasser, Hadi Ghanem, Amira Bekdash, Stephen H. Leppla, Shihui Liu, Vicky Najjar, Ralph J. Abi-Habib, Manal Darwish, Ali Bazerbachi, Marwan Ghosn
Publikováno v:
Translational Oncology, Vol 8, Iss 5, Pp 347-357 (2015)
In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e1dced83f61e46098c4ecddfa17b76
Autor:
Chi-Chuan Lin, Zamal Ahmed, Zahra Timsah, Prince Jeyabal, Fernando A. Melo, Jonathan Berrout, Roger G. O'Neil, Paul G. Leonard, John E. Ladbury, Loren J. Stagg, Mikhail Bogdanov
Publikováno v:
Nature Structural & Molecular Biology. 21:180-188
FGFR2-expressing human cancer cells with low concentrations of the adaptor protein Grb2 show high prevalence for metastatic outcome. In nonstimulated cells, the SH3 domain (and not the SH2 domains) of Plcγ1 directly competes for a binding site at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5bc3d6d28f4561145bf0cb83dd60c7
https://doi.org/10.1038/nsmb.2752
https://doi.org/10.1038/nsmb.2752
Autor:
Anil K. Sood, Yiling Lu, Mihai Gagea, Jinsong Liu, John E. Ladbury, Guillermo N. Armaiz Pena, Gordon B. Mills, Charles V. Kingsley, Mikhail Bogdanov, Yong Zhou, Cristina Ivan, Courtney Vallien, Zamal Ahmed, Andrew B. Gladden, Mien Chie Hung, John F. Hancock, Xin Hu, Zahra Timsah, Gabriel Lopez-Berestein, Jonathan Berrout
In the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Grb2) and the phospholipase Plcγ1 compete for the same binding site on fibroblast growth factor receptor 2 (FGFR2). Reducing cellular Grb2 results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c397515c94062908abe4297b261c249
https://eprints.whiterose.ac.uk/89027/1/45329_2_merged_1435083598.pdf
https://eprints.whiterose.ac.uk/89027/1/45329_2_merged_1435083598.pdf
Autor:
Leonardo Mirandola, Maurizio Chiriva-Internati, Diane Duyen Thuy Nguyen, Naval Daver, Robert S. Bresalier, Zahra Timsah
Publikováno v:
Journal of Clinical Oncology. 36:TPS3136-TPS3136
TPS3136Background: Despite advances in understanding the biology of hematologic malignancies (HM) and solid malignancies (SM), and the availability of new treatment options, many patients with HM a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30fc79a8e104570f56971f9acc6d14b9
https://doi.org/10.1200/jco.2018.36.15_suppl.tps3136
https://doi.org/10.1200/jco.2018.36.15_suppl.tps3136
Autor:
Zahra, Timsah, Jonathan, Berrout, Milind, Suraokar, Carmen, Behrens, Juhee, Song, J Jack, Lee, Cristina, Ivan, Mihai, Gagea, Michael, Shires, Xin, Hu, Courtney, Vallien, Charles V, Kingsley, IgnacioI, Wistuba, John E, Ladbury
Publikováno v:
American journal of cancer research. 5(10)
Lung adenocarcinoma is characterized by complex biology involving alterations at the genomic and protein expression levels. FGFR2 mutation and/or amplification are key drivers of disease progression and drug resistance in lung adenocarcinoma patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::241bdd7aedacda8917c5bb47a74370d2
https://pubmed.ncbi.nlm.nih.gov/26693065
https://pubmed.ncbi.nlm.nih.gov/26693065
Autor:
John E. Ladbury, Chi-Chuan Lin, Kin Man Suen, Nathan P. Cook, Angel A. Martí, Zahra Timsah, Gilbert R. Lee, Zamal Ahmed, Mihai Gagea
Publikováno v:
Nature Communications. 6
Nature Communications 6, Article number: 7354 (2015); Published: 24 June 2015; Updated: 3 August 2015. In this Article, there are errors in the labelling of the y axes in Figs 2 and 3. In both figures, ‘Fluorescence intensity’ should read ‘Numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae181b729af4a1637a2a867dc8cb8f2
https://doi.org/10.1038/ncomms9007
https://doi.org/10.1038/ncomms9007