Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zahra, Moghadamchargari"'
Autor:
Scott A. Cameron, Lawrence Harris, Arthur Laganowsky, Zahra Moghadamchargari, Dan Torres, James C. Sacchettini, Inna Krieger, Thomas D. Meek, Drake M. Mellott
Publikováno v:
Journal of the American Chemical Society. 143:17666-17676
The isocitrate lyase paralogs of Mycobacterium tuberculosis (ICL1 and 2) are essential for mycobacterial persistence and constitute targets for the development of antituberculosis agents. We report that (2R,3S)-2-hydroxy-3-(nitromethyl)succinic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c351d3ec7a29a2edb7258f6679913f0a
https://doi.org/10.1021/jacs.1c07970
https://doi.org/10.1021/jacs.1c07970
Autor:
Thomas D. Meek, Drake M. Mellott, Truc Viet Pham, Inna Krieger, Zahra Moghadamchargari, Kevin Chen, James C. Sacchettini, Arthur Laganowsky
Publikováno v:
ACS Chemical Biology. 16:463-470
The isocitrate lyases (ICL1/2) are essential enzymes of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. At present, no ICL1/2 inhibitors have progressed to clinical evaluation, despite extensive drug discovery efforts. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dfbb8c22455b348ac4f277806bb4fa3
https://doi.org/10.1021/acschembio.0c00740
https://doi.org/10.1021/acschembio.0c00740
Autor:
David H. Russell, He Mirabel Sun, Mehdi Shirzadeh, Zahra Moghadamchargari, Hays S. Rye, Jacob W. McCabe, Thomas E. Walker, David E. Clemmer, Arthur Laganowsky, Andrew Roth
Publikováno v:
J Am Chem Soc
Chaperonins are nanomachines that harness ATP hydrolysis to power and catalyze protein folding, chemical action that is directly linked to the maintenance of cell function through protein folding/refolding and assembly. GroEL and the GroEL-GroES comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be4072cb1756453072d0f580287805d
https://doi.org/10.33774/chemrxiv-2021-vk20s-v2
https://doi.org/10.33774/chemrxiv-2021-vk20s-v2
Autor:
Drake M, Mellott, Dan, Torres, Inna V, Krieger, Scott A, Cameron, Zahra, Moghadamchargari, Arthur, Laganowsky, James C, Sacchettini, Thomas D, Meek, Lawrence D, Harris
Publikováno v:
Journal of the American Chemical Society. 143(42)
The isocitrate lyase paralogs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e2d79910cefba39a1be2d327f73024a
https://pubmed.ncbi.nlm.nih.gov/34664502
https://pubmed.ncbi.nlm.nih.gov/34664502
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c07682323671b2ae0b15b4314ed2ab4
https://pubmed.ncbi.nlm.nih.gov/34288674
https://pubmed.ncbi.nlm.nih.gov/34288674
Autor:
Jacob W. McCabe, David H. Russell, Zahra Moghadamchargari, Arthur Laganowsky, Mehdi Shirzadeh, Michael L. Poltash
Publikováno v:
Chemical Communications. 55:4091-4094
The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9779fd5309969b02444df319b5373c8e
https://doi.org/10.1039/c9cc00682f
https://doi.org/10.1039/c9cc00682f
Autor:
Samantha Schrecke, David H. Russell, Zahra Moghadamchargari, Arthur Laganowsky, Minglei Zhao, Chang Liu, Charles Packianathan, Mehdi Shirzadeh
Publikováno v:
Proc Natl Acad Sci U S A
Ras is regulated by a specific guanine nucleotide exchange factor Son of Sevenless (SOS), which facilitates the exchange of inactive, GDP-bound Ras with GTP. The catalytic activity of SOS is also allosterically modulated by an active Ras (Ras–GTP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fbcd47635cfd027efcbbb773d0935c
https://europepmc.org/articles/PMC8000204/
https://europepmc.org/articles/PMC8000204/
Autor:
Truc Viet, Pham, Drake M, Mellott, Zahra, Moghadamchargari, Kevin, Chen, Inna, Krieger, Arthur, Laganowsky, James C, Sacchettini, Thomas D, Meek
Publikováno v:
ACS chemical biology. 16(3)
The isocitrate lyases (ICL1/2) are essential enzymes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caf5afb7680be2a903e3c4684b37e7da
https://pubmed.ncbi.nlm.nih.gov/33688722
https://pubmed.ncbi.nlm.nih.gov/33688722
Autor:
David H. Russell, Mehdi Shirzadeh, Frank M. Raushel, Xueyun Zheng, David E. Clemmer, Arthur Laganowsky, Jamison P. Huddleston, Zahra Moghadamchargari
Publikováno v:
Biochemistry
Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from an active to inactive state by both intrinsic and GTPase-activating protein (GAP)-stimulated hydrolysis. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec59c3c0b34a9dfb527d6cd49242944
https://europepmc.org/articles/PMC7196336/
https://europepmc.org/articles/PMC7196336/