Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zahide Ozer"'
Publikováno v:
EBioMedicine, Vol 1, Iss 1, Pp 16-28 (2014)
The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells cau
Externí odkaz:
https://doaj.org/article/a5f70dac05f642cdb89ecf3f9ac0aadd
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71302 (2013)
Diminished Ikaros function has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL), the most common form of childhood cancer. Therefore, a stringent regulation of Ikaros is of paramount importance for normal lymphocyte ontogeny.
Externí odkaz:
https://doaj.org/article/607ba95772884b01bdd3ba20110abf62
Autor:
Richard Ting, Haluk Sayman, Fuad Nurili, Feifei An, Omer Aras, Hüseyin Çakıroğlu, Zahide Ozer
Publikováno v:
J Med Chem
The β-diketone moiety is commonly present in many anticancer drugs, antibiotics, and natural products. We describe a general method for radiolabeling β-diketone-bearing molecules with fluoride-18. Radiolabeling is carried out via (18)F-(19)F isotop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0052e18a7a335439917f1c858c60a9f5
https://doi.org/10.1021/acs.jmedchem.0c00997
https://doi.org/10.1021/acs.jmedchem.0c00997
Autor:
Zahide Ozer, Hong Ma, Fatih M. Uckun, Rebecca Rose, Dorothea E. Myers, Osmond J. D'Cruz, Sanjive Qazi
Publikováno v:
Journal of Clinical Investigation. 125:1006-1018
Patients with B cell precursor acute lymphoblastic leukemia (BPL) respond well to chemotherapy at initial diagnosis; however, therapeutic options are limited for individuals with BPL who relapse. Almost all BPL cells express CD19, and we recently clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5e24b5563f49c447e2cf8c73b30317
https://doi.org/10.1172/jci76610
https://doi.org/10.1172/jci76610
Publikováno v:
EBioMedicine, Vol 1, Iss 1, Pp 16-28 (2014)
EBioMedicine
EBioMedicine
The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2a57fbca3db1dfbb86599d8d5ccd2b
http://www.sciencedirect.com/science/article/pii/S2352396414000218
http://www.sciencedirect.com/science/article/pii/S2352396414000218
Publikováno v:
British Journal of Haematology. 156:89-98
Gene expression profiling (GEP) of primary leukaemic cells (PLC) from 157 paediatric B-lineage acute lymphoblastic leukaemia (ALL) patients, including a direct comparison of matched pair initial diagnosis versus first relapse leukaemic specimens, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9d01770ba2ae56f6b5729fffb250776
https://doi.org/10.1111/j.1365-2141.2011.08901.x
https://doi.org/10.1111/j.1365-2141.2011.08901.x
Autor:
Zahide Ozer, Hong Ma, Kim D. Janda, Sanjive Qazi, Amanda L. Garner, Fatih M. Uckun, Jason J. Pitt
Publikováno v:
British Journal of Haematology. 153:741-752
We present previously unknown evidence that the immunoglobulin heavy chain binding protein BIP/HSPA5, also known as glucose regulated protein (GRP)78, serving as a pivotal component of the pro-survival axis of the unfolded protein response (UPR) sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53ff40c559e6a885512a97294d0f3e5
https://doi.org/10.1111/j.1365-2141.2011.08671.x
https://doi.org/10.1111/j.1365-2141.2011.08671.x
Publikováno v:
British Journal of Haematology. 153:15-23
We report the cloning and characterization of a novel 54-kDa high-mobility group (HMG)-box protein as the ligand for the human pan-B cell co-receptor CD19 (CD19-L), which interacts with the extracellular domain of CD19 in trans. CD19-L is the first C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03df24575cf944585a9e758bded64c43
https://doi.org/10.1111/j.1365-2141.2011.08583.x
https://doi.org/10.1111/j.1365-2141.2011.08583.x
Publikováno v:
British Journal of Haematology. 136:574-589
Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cfb146d1f614d175e5376e27c81bd7
https://doi.org/10.1111/j.1365-2141.2006.06468.x
https://doi.org/10.1111/j.1365-2141.2006.06468.x
Autor:
Chen Mao, Barbara Waurzyniak, Sharon Pendergrass, Francis Rajamohan, Fatih M. Uckun, Zahide Ozer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:1052-1061
A molecular model of pokeweed antiviral protein (PAP)-RNA interactions was used to rationally engineer FLP-102( 151 AA 152 ) and FLP-105( 191 AA 192 ) as nontoxic PAPs with potent anti-human immunodeficiency virus (anti-HIV) activities. FLP-102 and F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88d18dd7a9a7a9f7acf0db99d7f0323
https://doi.org/10.1128/aac.47.3.1052-1061.2003
https://doi.org/10.1128/aac.47.3.1052-1061.2003