Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zahid Bonday"'
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Figures and Materials and Metholds from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b51e86e9b7513857bdd252443925fa
https://doi.org/10.1158/1535-7163.22485351.v1
https://doi.org/10.1158/1535-7163.22485351.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 2 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45515ad58f3fa654f42c307ee91c362b
https://doi.org/10.1158/1535-7163.22485345
https://doi.org/10.1158/1535-7163.22485345
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 1 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26232b2120ba418d9671855d8e245c
https://doi.org/10.1158/1535-7163.22485348.v1
https://doi.org/10.1158/1535-7163.22485348.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 3 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab078191ad592debcca47d0ad3279d38
https://doi.org/10.1158/1535-7163.22485342.v1
https://doi.org/10.1158/1535-7163.22485342.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Although clinical responses in liquid tumors and certain lymphomas have been reported, the clinical efficacy of histone deacetylase inhibitors in solid tumors has been limited. This may be in part due to the poor pharmacokinetic of these drugs, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfd470f6ae571ff56fa8b9560145061
https://doi.org/10.1158/1535-7163.c.6531900
https://doi.org/10.1158/1535-7163.c.6531900
Autor:
Anke Klippel, Rui Wang, Loredana Puca, Andrew Lee Faber, Weihua Shen, Shripad V. Bhagwat, Kannan Karukurichi, Feiyu Fred Zhang, Carmen Perez, Ramon Rama, Ana Ramos, Yi Zheng, Zahid Bonday, James Thomas, Harold B. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, Mark Hicks II, Sophie Callies, Brian Mattioni, Laurie LeBrun, Jim Durbin, Erin Anderson, Chris Mayne, Edward Kesicki, Gabrielle Kolakowski, Steven W. Andrews, Barbara J. Brandhuber
Publikováno v:
Molecular Cancer Therapeutics. 20:P142-P142
Phosphoinositide 3-kinase alpha (PI3Kα) H1047R mutations are activating oncogenic events that occur in ~15% of advanced breast cancers. While there is one PI3Kα inhibitor FDA-approved for patients with PI3Kα-mutated breast cancer, and many others
Autor:
Chang Kai Soh, Kay Lin Goh, Meredith Williams, Kantharaj Ethirajulu, Haishan Wang, Zahid Bonday, Jeanette Marjorie Wood, Miah Kiat Goh, Kee Chuan Goh, Brian Dymock, Anders Poulsen, Stéphanie Blanchard, Mohammed Khalid Pasha, Chai Ping Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2880-2884
A series of 2-anilino substituted 4-aryl-8H-purines were prepared as potent inhibitors of PDK1, a serine-threonine kinase thought to play a role in the PI3K/Akt signaling pathway, a key mediator of cancer cell growth, survival and tumorigenesis. The
Autor:
Dizhong Chen, Mui Ling Khoo, Joyce Wei Wei Chang, Kee Chuan Goh, Xin Liu, Anders Poulsen, Siok Kun Goh, Kay Lin Goh, Kanda Sangthongpitag, Niefang Yu, Lye Pek Ling, Zahid Bonday, Changyong Hu, Xukun Wang, Xiaofeng Wu, Brian Dymock, Hwee Hoon Khng, Eric T. Sun, Haishan Wang, Melvin Ng, Lijuan Fang, Ethirajulu Kantharaj, Weiping Deng, Jeanette Marjorie Wood, Ting Lu, Ken Chi Lik Lee, Pauline Yeo
Publikováno v:
Journal of Medicinal Chemistry. 54:4694-4720
A series of 3-(1,2-disubstituted-1H-benzimidazol-5-yl)-N-hydroxyacrylamides (1) were designed and synthesized as HDAC inhibitors. Extensive SARs have been established for in vitro potency (HDAC1 enzyme and COLO 205 cellular IC(50)), liver microsomal
Autor:
Ken Lee, Wai Chung Ong, Kanda Sangthongpitag, Eric T. Sun, Siok Kun Goh, Xukun Wang, Haishan Wang, Melvin Ng, Ze-Yi Lim, Zahid Bonday, Yan Zhou, Hwee Hoon Khng, Ting Lu, Xiaofeng Wu, Kee Chuan Goh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3314-3321
Thirty-six novel acylurea connected straight chain hydroxamates were designed and synthesized. Structure–activity relationships (SAR) were established for the length of linear chain linker and substitutions on the benzoylurea group. Compounds 5g, 5
Autor:
Anders Poulsen, Kee Chuan Goh, Ee Ling Teo, Chee Pang Ng, Stéphanie Blanchard, Evelyn Tan, Wai Chung Ong, Kay Lin Goh, Weiping Deng, Angeline C.-H. Lee, Eric T. Sun, Anthony D. William, Noah Tu, Zahid Bonday
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2443-2447
A series of alkenyl indazoles were synthesized and evaluated in Aurora kinase enzyme assays. Several promising leads were optimized for selectivity towards Aurora B. Excellent binding affinity and good selectivity were achieved with optimized compoun