Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zahid, Padamsey"'
Autor:
Zahid Padamsey, Danai Katsanevaki, Patricia Maeso, Manuela Rizzi, Emily E Osterweil, Nathalie L Rochefort
Publikováno v:
eLife, Vol 12 (2024)
Mammals have evolved sex-specific adaptations to reduce energy usage in times of food scarcity. These adaptations are well described for peripheral tissue, though much less is known about how the energy-expensive brain adapts to food restriction, and
Externí odkaz:
https://doaj.org/article/ee4b8425f0bc41fbb6f09fb759991d08
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract The synapse is typically viewed as a single compartment, which acts as a linear gain controller on incoming input. Traditional plasticity rules enable this gain control to be dynamically optimized by Hebbian activity. Whilst this view nicely
Externí odkaz:
https://doaj.org/article/bff5e6378a044246a5f8da982ee0189e
Publikováno v:
eLife, Vol 8 (2019)
Active dendrites impact sensory processing and behaviour. However, it remains unclear how active dendritic integration relates to somatic output in vivo. We imaged semi-simultaneously GCaMP6s signals in the soma, trunk and distal tuft dendrites of la
Externí odkaz:
https://doaj.org/article/f673fb50520247ce99ef97ec4a4183ee
Autor:
Alexander F. Jeans, Fran C. van Heusden, Bashayer Al-Mubarak, Zahid Padamsey, Nigel J. Emptage
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 341-350 (2017)
Summary: Voltage-dependent Ca2+ channels (VGCC) represent the principal source of Ca2+ ions driving evoked neurotransmitter release at presynaptic boutons. In mammals, presynaptic Ca2+ influx is mediated mainly via P/Q-type and N-type VGCC, which dif
Externí odkaz:
https://doaj.org/article/86b6783b1b2447e7a9b44b8a866bf49d
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 11 (2019)
Despite evidence that presynaptic efficacy and plasticity influence circuit function and behavior in vivo, studies of presynaptic function remain challenging owing to the difficulty of assessing transmitter release in intact tissue. Electrophysiologi
Externí odkaz:
https://doaj.org/article/25f82ba23b0b47da9343c70098862311
Autor:
Zahid Padamsey, Nathalie L. Rochefort
Publikováno v:
Padamsey, Z & Rochefort, N L 2022, ' Paying the brain’s energy bill ', Current Opinion in Neurobiology . https://doi.org/10.1016/j.conb.2022.102668
How have animals managed to maintain metabolically expensive brains given the volatile and fleeting availability of calories in the natural world? Here we review studies in support of three strategies that involve: 1) a reallocation of energy from pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd5eacbeea65f63760b26282c380b4f
https://pubmed.ncbi.nlm.nih.gov/36571958
https://pubmed.ncbi.nlm.nih.gov/36571958
Publikováno v:
Communicative & Integrative Biology, Vol 10, Iss 5-6 (2017)
A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca2+ stores, regulated by the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). We previously
Externí odkaz:
https://doaj.org/article/8c86406e1e4f497e9ada23e3cde58bdb
Publikováno v:
eLife, Vol 6 (2017)
Hebbian plasticity is thought to require glutamate signalling. We show this is not the case for hippocampal presynaptic long-term potentiation (LTPpre), which is expressed as an increase in transmitter release probability (Pr). We find that LTPpre ca
Externí odkaz:
https://doaj.org/article/e2d12f8dfa7c4c80b079675bdd142527
Autor:
Zahid Padamsey, Nathalie L. Rochefort
Publikováno v:
Neuron. 108:1016-1019
In this issue of Neuron, Jordan and Keller (2020) explore subthreshold computations underlying predictive coding using whole-cell recordings in mouse visual cortex. Their findings suggest that layer 2/3, but not layer 5/6, neurons compute prediction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae3d26191923a14e6f2c4a4dd525e408
https://doi.org/10.1016/j.neuron.2020.12.005
https://doi.org/10.1016/j.neuron.2020.12.005
Publikováno v:
Molecular Brain
Molecular Brain, Vol 13, Iss 1, Pp 1-10 (2020)
Molecular Brain, Vol 13, Iss 1, Pp 1-10 (2020)
The synapse is typically viewed as a single compartment, which acts as a linear gain controller on incoming input. Traditional plasticity rules enable this gain control to be dynamically optimized by Hebbian activity. Whilst this view nicely captures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dafafd7e11b4a576485002b590ab99
https://pubmed.ncbi.nlm.nih.gov/32434549
https://pubmed.ncbi.nlm.nih.gov/32434549